Search

A Real Plan for Making Drugs Affordable–and Promoting Innovation, Too “This book is a necessity for understanding the pharmaceutical industry. Both the pluses and minuses of the present system are set forth with a judicious combination of historical narrative, economic analysis, and statistical data. The highly original proposals for reform will be a major stimulant to analysis and policy-making.” –Kenneth Arrow, Nobel Laureate in Economics, Professor Emeritus, Stanford University “This is a timely book by authors who know what they are talking about. They tackle a big problem: rising drug prices that are threatening to overwhelm us all–and especially those with limited or absent health care insurance. Will we drive people overseas for healthcare? Will there be social unrest? This book describes the problem and then offers a solution. Worth a careful read by everyone, pharmaceutical manufacturers and government policymakers especially.” –Roger Williams, M.D., Chief Executive Officer of the United States Pharmacopeia and a former senior official of the Food and Drug Administration “This book confounds two sets of skeptics: Those who say there’s no way to resolve the conflict between the need to fund pharmaceutical research and our desire to keep medicine affordable; and those who think that economics never has anything good to say.” –Honorable Barney Frank, Congressman from Massachusetts “This book comes at the right time and could become the starting point of discussions, which will eventually lead us into new era in the healthcare care industry. It will without a doubt become a must for insiders of the pharma- and biotech industries.” –Dr. Jürgen Drews, retired President of Roche Pharmaceutical Group Global Research Acknowledgments viii About the Authors ix Introduction xi Chapter 1: Drugs and Drug Prices 1 Chapter 2: The American Way to Discover Drugs 21 Chapter 3: The Drug Industry Today 39 Chapter 4: Are Drug Companies Risky? 59 Chapter 5: How Not to Lower Drug Prices 77 Chapter 6: Squandering R & D Resources 103 Chapter 7: How to Lower Drug Prices 129 Appendix: Our Solution in Detail 155 Index 177

Explores the problem of high drug prices by taking a close look at the science of drug development, how the drug industry operates, how new drugs are discovered, and how the government affects and controls these processes. By examining recent changes in the pharmaceutical industry in more depth, the authors explain how more radical changes can both reduce prices and improve the flow of new drugs.

This book provides an integrated treatment of the structure and function of nucleic acids, proteins, and glycans, including thorough coverage of relevant computational biochemistry. The text begins with an introduction to the biomacromolecules, followed by discussion of methods of isolation and purification, physiochemical and biochemical properties, and structural characteristics. The next section of the book deals with sequence analysis, analysis of conformation using spectroscopy, chemical synthesis, and computational approaches. The following chapters discuss biomolecular interactions, enzyme action, gene transmission, signal transduction, and biomacromolecular informatics. The author concludes with presenting the latest findings in genomics, proteomics, glycomics, and biomacromolecular evolution. This text is an invaluable resource for research professionals wishing to move into genomics, proteomics, and glycomics research. It is also useful for students in biochemistry, molecular biology, bioengineering, biotechnology, and bioinformatics.

Psychology recognises no borders. The relationships between people and the groups they form are determined by similar principles no matter where in the world they come from. This book has been written to introduce students from all countries and backgrounds to the exciting field of social psychology. Recognising the limitations that come from studying the subject through the lens of any one culture, James Alcock and Stan Sadava have crafted a truly international social psychology book for the modern era. Based on classic and cutting-edge scholarship from across the world, An Introduction to Social Psychology encourages mastery of the basics as well as critical thinking. Incorporating relevant insights from social neuroscience, evolutionary theory and positive psychology, it offers: Chapters on crowd behaviour and applied social psychology Discussion of new means of social interaction, including social media Relevant insights from social neuroscience, evolutionary theory and positive psychology A companion website features extensive additional resources for students and instructors

What do Osama bin Laden, Adolph Hitler, David Koresh, Jim Jones, Gene Applewhite, and the slayers of abortion doctors all have in common? All of them based their dangerous and destructive actions, to a large extent, on a message they believed they received from God. The receipt of messages from God is known by many religions as 'spiritual gifts theology.' Expounding on concepts developed in earlier work, author Stan Lindsay analyzes the religious motives behind the dangerous behavior of some individuals and organizations, presents key indicators of psychotic entelechy, and proposes curative methods.

This comprehensive text offers a solid introduction to the biochemical principles and skills required for any researcher applying computational tools to practical problems in biochemistry. Each chapter includes an introduction to the topic, a review of the biological concepts involved, a discussion of the programming and applications used, key references, and problem sets and answers. Providing detailed coverage of biochemical structures, enzyme reactions, metabolic simulation, genomic and proteomic analyses, and molecular modeling, this is the perfect resource for students and researchers in biochemistry, bioinformatics, bioengineering and computational science.

An analytical bibliography that contains 7407 references, covering the Egyptian prehistory (palaeolithic, neolithic and predynastic) as well as the period of the first two dynasties.

Proper diagnosis, pathogens, management, antibiotic resistance, and prevention of AOM are reviewed. Basis for antibiotic selection is discussed in detail and appropriate first-, second-, and third-line antibiotic therapies are presented. Clinical issues, such as management of treatment failures, criteria for tympanostomy tubes, and improper use of antibiotics, are reviewed.