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Nephrology is an important speciality; patients with acute orchronic kidney failure are encountered in every medical andsurgical speciality, as well as in general practice. On mostgeneral medical rotations and on most surgical wards there arepatients with renal problems. Renal medicine is taught on rotationduring degree courses, and Foundation training programmesfrequently include attachments in nephrology, urology, and renaltransplantation. Nephrology: Clinical Cases Uncoveredcontains clinical presentations with real-life patient cases andoutcomes as seen on the wards and in exams, and leads studentsthrough a practical approach to diagnosis and management of kidneydisease. Following a question-answer approach, including self-assessmentmaterial and a ‘refresher’ section on the basic scienceof this clinical area, Nephrology: Clinical Cases Uncoveredfeatures investigations and the treatment options available forpatients with renal disease, including those requiring renalreplacement therapy with dialysis and transplantation. Difficultconcepts are clarified, using simple diagrams to explain the linkbetween pathology and clinical presentation. Nephrology: Clinical Cases Uncovered is ideal for medicalstudents, junior doctors on the Foundation Programme, GP trainees,and specialist nurses and nurse practitioners. This book is also auseful refresher for nephrology trainees at the beginning of theirspecialist training programme.

The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

Nephrology is an important speciality; patients with acute orchronic kidney failure are encountered in every medical andsurgical speciality, as well as in general practice. On mostgeneral medical rotations and on most surgical wards there arepatients with renal problems. Renal medicine is taught on rotationduring degree courses, and Foundation training programmesfrequently include attachments in nephrology, urology, and renaltransplantation. Nephrology: Clinical Cases Uncoveredcontains clinical presentations with real-life patient cases andoutcomes as seen on the wards and in exams, and leads studentsthrough a practical approach to diagnosis and management of kidneydisease. Following a question-answer approach, including self-assessmentmaterial and a ‘refresher’ section on the basic scienceof this clinical area, Nephrology: Clinical Cases Uncoveredfeatures investigations and the treatment options available forpatients with renal disease, including those requiring renalreplacement therapy with dialysis and transplantation. Difficultconcepts are clarified, using simple diagrams to explain the linkbetween pathology and clinical presentation. Nephrology: Clinical Cases Uncovered is ideal for medicalstudents, junior doctors on the Foundation Programme, GP trainees,and specialist nurses and nurse practitioners. This book is also auseful refresher for nephrology trainees at the beginning of theirspecialist training programme.

The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks. This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly-illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

Fcγ receptors (FcγR) mediate many effector functions of antibody and are critical for defense against pathogens, including bacteria, viruses, and parasites. A number of single nucleotide polymorphisms have been identified in both activating and inhibitory FcγR genes that affect either the binding affinity for IgG or receptor function. Reviewing the available evidence from murine knockout mice, in vitro studies utilizing human cells, and genetic studies in humans, the current view on the role of FcγR polymorphisms in susceptibility to infection will be summarized here. Genetic studies have often yielded conflicting results, which may be due to small sample size or the inherent difficulties associated with genotyping the FCGR locus, or they may reflect differences in the functional importance of interactions between FcγR and its ligands (IgG versus CRP) in differing clinical manifestations of infectious disease. The engagement of the inhibitory FcγR limits the proinflammatory response initiated by FcγR ligation. FCGR polymorphisms that favor activating FcγR may result in excessive inflammation that is deleterious to the host, despite its efficacy in eliminating the pathogen. Overall, pathogen encounter is likely to be the main factor driving the retention of FCGR polymorphisms within the gene pool. Evidence suggests that potent infections, such as malaria, have exerted a significant evolutionary pressure on the maintenance and prevalence of FcγR polymorphisms in different populations.

First published in 1959, this innovative narrative - a mix of 'poet's novel' and 'whodunnit' - is set in the fictional valleys town of Cilhendre at the time of the Lock Out that followed the General Strike of May 1926.

Jude is the owner of a unique antiques shop in Cambridge. She makes it her mission to match customers with the special something that they are missing, a talisman to bring them what their heart desires. Unfortunately, Jude's life is not overflowing with the love she wishes for. However, when she 'inherits' a niece that she never knew existed, doubling her meagre family overnight, Jude's life is soon set to get a lot less lonely and a lot more interesting. Viola is a single-minded perfectionist whose only heart's desire is the position of Head Chef at one of Cambridge's most prestigious restaurants. But when Viola keeps bumping into a widower, Mathieu, she begins to discover that there's more to life beyond the kitchen.

"Jude is the owner of a rather special antiques shop in Cambridge. She finds all of the joy in her life matching people with the special something that they are missing, a talisman that will help bring them just what their heart most desires. Although Jude's life is certainly not overflowing with the love she would wish for. When she inherits' a niece that she never knew existed, doubling her meagre family overnight, life is set to get a lot less empty and a lot more interesting. Viola is on a quest for perfection and the top job of Head Chef at one of Cambridge's most prestigious restaurants to the exclusion of all else. When her path continues to cross that of widower and food historian Mathieu, she starts to see that there's a lot to life beyond the kitchen that she's been missing out on"--