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Twenty years after the beginning of the Human Genome Project, what has the world learned about the way life replicates? In the tradition of Arthur Kornberg's classic work, DNA Replication (CH, Oct'80), this new book covers all the basics and brings the story up-to-date, including applications to human diseases and connections to understanding the mechanisms of evolution. Even though their coverage is comprehensive and includes many technical details, DePamphilis (NIH) and Bell (Oxford Univ., UK) have succeeded in providing an accessible work that undergraduate students in their first molecular genetics class can easily read and understand. At the same time, this book has much to offer graduate students and researchers in the field. Many excellent tables summarize the information in each chapter. The volume also includes a glossary, clear illustrations, and chapter references. As the authors note in their preface, "... nothing is more fundamental to life than the ability to reproduce." This book is an excellent reference for anyone who is interested in understanding the fundamentals of life. Summing Up: Highly recommended. All academic libraries; lower-division undergraduates and above. Lower-division Undergraduates; Upper-division Undergraduates; Graduate Students; Researchers/Faculty. Reviewed by C. A. Klevickis.