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An "elegant", "engrossing" (Carol Tavris, Wall Street Journal) examination of what we think we know about the brain and why -- despite technological advances -- the workings of our most essential organ remain a mystery. "I cannot recommend this book strongly enough."--Henry Marsh, author of Do No Harm For thousands of years, thinkers and scientists have tried to understand what the brain does. Yet, despite the astonishing discoveries of science, we still have only the vaguest idea of how the brain works. In The Idea of the Brain, scientist and historian Matthew Cobb traces how our conception of the brain has evolved over the centuries. Although it might seem to be a story of ever-increasing knowledge of biology, Cobb shows how our ideas about the brain have been shaped by each era's most significant technologies. Today we might think the brain is like a supercomputer. In the past, it has been compared to a telegraph, a telephone exchange, or some kind of hydraulic system. What will we think the brain is like tomorrow, when new technology arises? The result is an essential read for anyone interested in the complex processes that drive science and the forces that have shaped our marvelous brains.

A new “textual studies” and archival approach to the investigation of works of new media and electronic literature that applies techniques of computer forensics to conduct media-specific readings of William Gibson's electronic poem “Agrippa,” Michael Joyce's Afternoon, and the interactive game Mystery House. In Mechanisms, Matthew Kirschenbaum examines new media and electronic writing against the textual and technological primitives that govern writing, inscription, and textual transmission in all media: erasure, variability, repeatability, and survivability. Mechanisms is the first book in its field to devote significant attention to storage—the hard drive in particular—arguing that understanding the affordances of storage devices is essential to understanding new media. Drawing a distinction between “forensic materiality” and “formal materiality,” Kirschenbaum uses applied computer forensics techniques in his study of new media works. Just as the humanities discipline of textual studies examines books as physical objects and traces different variants of texts, computer forensics encourage us to perceive new media in terms of specific versions, platforms, systems, and devices. Kirschenbaum demonstrates these techniques in media-specific readings of three landmark works of new media and electronic literature, all from the formative era of personal computing: the interactive fiction game Mystery House, Michael Joyce's Afternoon: A Story, and William Gibson's electronic poem “Agrippa.”

The years between 1700 and 1900 witnessed a fundamental transition in attitudes towards science, as earlier concepts of natural philosophy were replaced with a more modern conception of science. This process was by no means a simple progression, and the changing attitudes to science was marked by bitter arguments and fundamental differences of opinion, many of which are still not entirely resolved today. Approaching the subject from a number of cultural angles, the essays in this volume explore the fluid relationship between science and belief during this crucial period, and help to trace the development of science as an independent field of study that did not look to religion to provide answers to the workings of the universe. Taking a broadly chronological approach, each essay in this book addresses a theme that helps illuminate these concerns and highlights how beliefs - both religious and secular - have impinged and influenced the scientific world. By addressing such key issues such as the ongoing debate between Christian fundamentalists and followers of Darwin, and the rise of 'respectable atheism', fascinating insights are provided that help to chart the ever-shifting discourse of science and beliefs.

Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.

Mumford-Tate groups are the fundamental symmetry groups of Hodge theory, a subject which rests at the center of contemporary complex algebraic geometry. This book is the first comprehensive exploration of Mumford-Tate groups and domains. Containing basic theory and a wealth of new views and results, it will become an essential resource for graduate students and researchers. Although Mumford-Tate groups can be defined for general structures, their theory and use to date has mainly been in the classical case of abelian varieties. While the book does examine this area, it focuses on the nonclassical case. The general theory turns out to be very rich, such as in the unexpected connections of finite dimensional and infinite dimensional representation theory of real, semisimple Lie groups. The authors give the complete classification of Hodge representations, a topic that should become a standard in the finite-dimensional representation theory of noncompact, real, semisimple Lie groups. They also indicate that in the future, a connection seems ready to be made between Lie groups that admit discrete series representations and the study of automorphic cohomology on quotients of Mumford-Tate domains by arithmetic groups. Bringing together complex geometry, representation theory, and arithmetic, this book opens up a fresh perspective on an important subject.

Sport and the Home Front contributes in significant and original ways to our understanding of the social and cultural history of the Second World War. It explores the complex and contested treatment of sport in government policy, media representations and the everyday lives of wartime citizens. Acknowledged as a core component of British culture, sport was also frequently criticised, marginalised and downplayed, existing in a constant state of tension between notions of normality and exceptionality, routine and disruption, the everyday and the extraordinary. The author argues that sport played an important, yet hitherto neglected, role in maintaining the morale of the British people and providing a reassuring sense of familiarity at a time of mass anxiety and threat. Through the conflict, sport became increasingly regarded as characteristic of Britishness; a symbol of the ‘ordinary’ everyday lives in defence of which the war was being fought. Utilised to support the welfare of war workers, the entertainment of service personnel at home and abroad and the character formation of schoolchildren and young citizens, sport permeated wartime culture, contributing to new ways in which the British imagined the past, present and future. Using a wide range of personal and public records – from diary writing and club minute books to government archives – this book breaks new ground in both the history of the British home front and the history of sport.

The early United States was a culture of the episode. In Episodic Poetics, Matthew Garrett merges narrative theory with social and political history to explain the early American fascination with the episodic, piecemeal plot. Since Aristotle's Poetics, the episode has been a vexed category of literary analysis, troubling any easy view of the subsumption of unwieldy narrative parts into well-plotted wholes. Garrett puts forward a new, dialectical theory of episodic form to recast this peculiar object of literary history, looking to the episode as a narrative unit smaller than the genre in order to give an account of all the period's major prose genres. Garrett shows how, in ways both magisterial and mundane, episodic forms gave variegated shape to the social, political, and economic conflicts that defined the moment of national formation. Episodic Poetics proposes a new method of reading and a new way of conceiving of literary history. The book asks how we might understand the cultural role of the episode as a literary micro-unit, one that forces us to read individual narratives in terms of an always partial and fraught development toward plot. Episodic Poetics combines theoretical reflection and historical rigor with careful readings of texts from the early American canon such as The Federalist, Benjamin Franklin's Autobiography, and the novels of Charles Brockden Brown, along with hitherto understudied texts and ephemera such as Washington Irving's Salmagundi, Susanna Rowson's Trials of the Human Heart and the memoirs of the metalworker and failed entrepreneur John Fitch. Garrett recounts literary history not as the easy victory of grand nationalist ambitions, but rather as a series of social struggles expressed through writers' recurring engagement with incompletely integrated forms.

This is the first full-length study of the organization that incubated Britain's most provocative and successful fascist movement. Exploring Sir Oswald Mosley's secession from Labour, his evolving politics and his eventual embrace of fascism, this book examines the process by which he transformed from Labour politician to fascist.