Search

Anti-Prostate Cancer Agents walks the readers through the anti-prostate cancer drug development pipeline from early discovery/design to clinical studies/applications. This book covers discovery/design, synthetic studies, preclinical evaluation, mechanism of action, structure-activity relationships, clinical studies/applications of anti-prostate cancer agents. This book provides insight on how the design and discovery process of anti-prostate cancer agents have evolved from androgen deprivation therapy to current androgen receptor antagonists/degraders. So far, no book focusing on the topic has been published. - Provides insight on how the design and discovery process of anti-prostate cancer agents have evolved - Explore the anti-prostate cancer drug development pipeline from early discovery/design to clinical studies/applications - Highlight the molecular targets and mechanism of action for anti-prostate cancer agents

A magnificently illustrated Chinese folklore tale about a tigress, a seer, a King, and the prince, who must leave his family and learn the ways of the tigers so that the war between man and animal can end. Deep in the Great Forest, a tigress is mourning the death of her tiger babies who have been killed by hunters. Seeking revenge, she attacks the villages, destroying houses and prompting the king to gather his army. But a seer named Lao Lao warns the king that if he angers the tigress further she will destroy the kingdom. Lao Lao counsels the king to give his own son to the tigress and promises that no harm will come to the boy. The next morning, the king brings the prince to the edge of the Great Forest and tells him, “Now you must go on alone.” To end the war between man and animal, the prince must forget his human ways and begin to learn what tigers know. The Tiger Prince was inspired by The Tigress, a late Shang dynasty bronze vessel in the Cernuschi Museum in Paris depicting a scene from the Chinese folktale of a baby raised by a tigress.

Pedagogy of Life takes its readers through the echoing stories of the half-century, historical Cultural Revolution of China to the literate lifeworld today. Rosa Hong Chen offers a gripping array of personal and kindred stories woven into the power of words and empathy of art through the volutes of writing and dancing for life, expressing genera of warm melancholy, weighty sensations, compulsive sobs, and refrained elation. It is for the existential history of individual lives and communal sharing that life creates a pedagogical condition of possible experiences. Life itself forms a historical and social path of human growth and maturation. In a philosophical and educational autoethnographical inquiry, the author examines the nature of literacy for those marginalized and oppressed; Chen explores how one's name and the ways in which that name is used affect a person's self-knowing and knowing of the world. This book exemplifies the idea that individuals' autobiographical stories are importantly connected to wider cultural, political, and social meaning and understanding. Pedagogy of Life echoes readers' musings, affects, relations, imagination, choice, learning, teaching, and much more, because we, each and all, have our own names, ways of uttering, writing, and dancing, and, ultimately, our own ways of living, knowing, and becoming.

This book discusses in detail the planning, design, construction and management of hydraulic structures, covering dams, spillways, tunnels, cut slopes, sluices, water intake and measuring works, ship locks and lifts, as well as fish ways. Particular attention is paid to considerations concerning the environment, hydrology, geology and materials etc. in the planning and design of hydraulic projects. It also considers the type selection, profile configuration, stress/stability calibration and engineering countermeasures, flood releasing arrangements and scouring protection, operation and maintenance etc. for a variety of specific hydraulic structures. The book is primarily intended for engineers, undergraduate and graduate students in the field of civil and hydraulic engineering who are faced with the challenges of extending our understanding of hydraulic structures ranging from traditional to groundbreaking, as well as designing, constructing and managing safe, durable hydraulic structures that are economical and environmentally friendly.

Nonlinear Estimation and Control of Automotive Drivetrains discusses the control problems involved in automotive drivetrains, particularly in hydraulic Automatic Transmission (AT), Dual Clutch Transmission (DCT) and Automated Manual Transmission (AMT). Challenging estimation and control problems, such as driveline torque estimation and gear shift control, are addressed by applying the latest nonlinear control theories, including constructive nonlinear control (Backstepping, Input-to-State Stable) and Model Predictive Control (MPC). The estimation and control performance is improved while the calibration effort is reduced significantly. The book presents many detailed examples of design processes and thus enables the readers to understand how to successfully combine purely theoretical methodologies with actual applications in vehicles. The book is intended for researchers, PhD students, control engineers and automotive engineers. Hong Chen is a professor at the State Key Laboratory of Automotive Simulation and Control, and the Department of Control Science and Engineering at Jilin University. Bingzhao Gao is an associate professor at the State Key Laboratory of Automotive Simulation and Control at Jilin University.

The Sinitic Civilization A Factual History through the Lens of Archaeology, Bronzeware, Astronomy, Divination, Calendar and the Annals The book covered the time span of history of the Sinitic civilization from antiquity, to the 3rd millennium B.C. to A.D. 85. A comprehensive review of history related to the Sinitic cosmological, astronomical, astrological, historical, divinatory, and geographical developments was given. All ancient Chinese calendars had been examined, with the ancient thearchs’ dates examined from the perspective how they were forged or made up. The book provides the indisputable evidence regarding the fingerprint of the forger for the 3rd century A.D. book Shangshu (remotely ancient history), and close to 50 fingerprints of the forger of the contemporary version of The Bamboo Annals. Using the watershed line of Qin Emperor Shihuangdi’s book burning of 213 B.C., the book rectified what was the original history before the book burning, filtered out what was forged after the book burning, sorted out the sophistry and fables that were rampant just prior to the book burning, and validated the history against the records in the oracle bones, bronzeware, and bamboo slips. The book covers 95-98% and more of the contents in the two ancient history annals of The Spring Autumn Annals and The Bamboo Annals. There are dedicated chapters devoted to interpreting Qu Yuan’s poem Asking Heaven (Tian Wen), the mythical book The Legends of Mountains & Seas (Shan Hai Jing), geography book Lord Yu’s Tributes (Yu Gong), and Zhou King Muwang’s Travelogue (Mu-tian-zi Zhuan). The book has appendices of two calendars: the first anterior quarter remainder calendar (247 B.C.-104 B.C./247 B.C.-85 A.D.) of the Qin Empire, as well as a conversion table of the sexagenary years of the virtual Yin-li (Shang dynasty) quarter remainder calendar versus the Gregorian calendar, that covers the years 2698 B.C. to 2018 A.D. Book I stops about the midpoint of the 242 years covered in Confucius’ abridged book The Spring & Autumn Annals (722-481 B.C.). Book II stops at Han Emperor Zhangdi (Liu Da, reign A.D. 76-88; actual reign Aug of A.D. 75-Feb of A.D. 88), with the A.D. 85 adoption of the Sifen-li posterior quarter remainder calendar premised on reverting to the sexagenary years of the virtual Yin-li (Shang dynasty) quarter remainder calendar, a calendar disconnected from the Jupiter’s chronogram, that was purportedly invented by the Confucians on basis of Confucius’ identifying the ‘qi-lin’ divine giraffe animal and wrapping up the masterpiece The Spring & Autumn Annals two years prior to death.

Chens picture book memoir of growing up during the Cultural Revolution in China.

In Himalayan Quest, city-dweller Pearl Hong Chen recounts the time she mustered the courage to trek a thousand kilometres to the roof of world. All it took was one step after another. In this spirited travel diary, Chen's anecdotes are supplemented by candid photos of the people, places, and landscapes she encountered along the way.

"The selection of materials is well balanced in breadth and depth, making the book an ideal graduate-level text for students in engineering, business, applied mathematics, and probability and statistics.

An innovative approach to teaching Chinese language and culture, using folk and popular songs. Offering an innovative approach to language learning, Chinese through Song helps students develop their language proficiency and music appreciation through the use of folk, popular, and art songs. Because songs emphasize the color, pronunciation, and intonation of every syllable, they can be a valuable tool for improving a student’s spoken language skills. By learning and performing the songs in this book, students will expand their vocabularies and improve their pronunciation, voice projection, and language expression—all while learning about Chinese culture in a fun and stimulating way. This revised and expanded edition includes thirty songs, many of them new to this edition. They feature lucid and vivid language, as well as beautiful and relatively simple melodies. They are good for voice development and can be practiced in different modes of performance, including solos, duets, rounds, and musical dramas. Each chapter comprises up to seven sections: (1) a song, including sheet music and lyrics in Chinese characters and pinyin Romanization; (2) a line-by-line English translation; (3) a vocabulary list designed for students who have completed at least one year of Chinese; (4) cultural notes that help students understand the historical and social context of the song; (5) language notes on the use of key words and important sentence patterns; (6) singing instructions, including remarks on interpretation and performance; and (7) language exercises for both classroom practice and homework assignments. Chinese through Song may be used in several ways: as the main textbook for an interdisciplinary, intermediate-level course, emphasizing both language acquisition and musical performance; as a supplement to regular Chinese language classes, from elementary through advanced levels; as a resource for extracurricular activities (for example, a Chinese chorus or a performance at a Chinese New Year party); and as a general songbook.