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For more than a hundred years, Galveston has lured visitors with the therapeutic effects of her warm Gulf waters. Today, Galveston is much more than just a beach, and with so many appealing year-round attractions, it's hard to know where to begin your adventure. With 100 Things to Do in Galveston Before You Die as your guide, you won't miss any of the history, art, festivals, and dining that bring visitors in droves and keep locals happy. Step inside Bishop's Palace, considered one of the best examples of Victorian architecture in the United States. Visit Katie's Seafood for a fresh Gulf catch or Gaido's Seafood Restaurant, but make sure to save room for its amazing Pecan Crunch Pie. Nurture your love for history and the arts by catching a show at The Grand 1894 Opera House. Take the kids to Moody Gardens to meet a penguin. And no visit to Galveston would be complete without getting some sand between your toes at Texas' most popular beach. Local co-authors Christine Ruiz Hopkins and Heidi Lutz bring their expert insiders' perspectives to this jam-packed guide full of hidden gems and top picks. You'll get the most from an island stay in Galveston by checking their carefully curated suggestions off your list.

In Equipping Christians for Kingdom Purpose in Their Work, Tom Lutz and Heidi Unruh offer advice to those who seek to influence the faith of people outside the church. Pastors, Christian educators, life coaches, workplace mentors, college professors, and any Christian who considers their vocation to be one of discipleship will find nourishment in this book. Few resources are designed for personal disciplers—those who connect with other believers on a personal basis with a deep interest in their spiritual growth. This book fills the gap. This one-of-a-kind resource shows how to disciple others in and for their work. Most “faith and work” books focus on pastors and church programs, or they speak directly to workers. But this resource comes to the aid of those who offer spiritual guidance to working Christians. This guide makes faith-and-work discipleship accessible to anyone who influences the faith of another. With short, readable chapters filled with case studies, examples, and practical resources, readers will learn how to equip others to fulfill their kingdom purpose in their work. Sample topics include: Principles for Effectively Connecting with Adult Learners Structure for One-on-One Discipleship Meetings Research on Vocational Discipleship and Kingdom-Centered Spiritual Maturity Various Leadership Models Scripture Passages on Being an Image-Bearer Selected Scriptures for Faith and Work Principles

Abstract: G proteins are major transducers of signals from G-protein coupled receptors (GPCRs). They are made up of [alpha], [beta], and [gamma] subunits, with 16 G[alpha], 5 G[beta] and 12 G[gamma] subunits. Though much is known about the specificity of G[alpha] subunits, the specificity of G[beta][gamma]s activated by a given GPCR and that activate each effector in vivo is not known. Here, we examined the in vivo G[beta][gamma] specificity of presynaptic [alpha]2a-adrenergic receptors ([alpha]2aARs) in both adrenergic (auto-[alpha]2aARs) and non-adrenergic neurons (hetero-[alpha]2aARs) for the first time. With a quantitative MRM proteomic analysis of neuronal G[beta] and G[gamma] subunits, and co-immunoprecipitation of tagged [alpha]2aARs from mouse models including transgenic FLAG-[alpha]2aARs and knock-in HA-[alpha]2aARs, we investigated the in vivo specificity of G[beta] and G[gamma] subunits to auto-[alpha]2aARs and hetero-[alpha]2aARs activated with epinephrine to understand the role of G[beta][gamma] specificity in diverse physiological functions such as anesthetic sparing, and working memory enhancement. We detected G[beta]2, G[gamma]2, G[gamma]3, and G[gamma]4 with activated auto [alpha]2aARs, whereas we found G[beta]4 and G[gamma]12 preferentially interacted with activated hetero-[alpha]2aARs. Further understanding of in vivo G[beta][gamma] specificity to various GPCRs offers new insights into the multiplicity of genes for G[beta] and G[gamma], and the mechanisms underlying GPCR signaling through G[beta][gamma] subunits