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This new multi-authored book reviews the current understanding of the role of thrombin in venous and arterial thrombosis and its inhibition in the clinical setting. Heparin, the most widely used antithrombotic, does not effectively regulate thrombin or its formation. Accumulating evidence suggests that other antithrombins are effective in some of the situations where heparin is not. Discussions include the current knowledge on antithrombotic prophylaxis and therapy, from the perspective of the role in thrombin in venous and arterial vascular disease, the limitations of the current anticoagulant therapies, and potential and limitations of newer antithrombins currently being tested in several experimental and clinical settings. Thrombin helps the clinician to better rationalize the use of specific antithrombins in the prevention and management of thrombotic disease and provides the basic scientist with a better understanding of the goals the clinician attempts to achieve with antithrombotic therapy.

Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.

This timely work deals with the application of biotechnologic innovations to improve health throughout the world. The text focuses on the role of vaccines, existing and proposed, in preventing and controlling diseases in the poorer countries. It clarifies the interrelations of science, technology, economics, epidemiology, and other disciplines needed to take a vaccine from concept to reality. The particular concerns of each participating group are discussed with ways to minimize risks and hazards. This book is essential reading for laboratory investigators, primarily in the industrialized world, who generate the products of biotechnology; administrators of public health programs in developing countries; and the evaluators, managers, production specialists, and others who make the product "from the bench to the bush". Students of medicine, immunology, public health, public policy, development studies, and related fields will find this book invaluable.

I was born in Tuckahoe, near Hillsborough, and about twelve miles from Easton, in Talbot county, Maryland. I have no accurate knowledge of my age, never having seen any authentic record containing it. By far the larger part of the slaves know as little of their ages as horses know of theirs, and it is the wish of most masters within my knowledge to keep their slaves thus ignorant. I do not remember to have ever met a slave who could tell of his birthday.