ADVANCED DRUG DELIVERY TECHNOLOGIES
Preface: Emulgels, microemulgels, and nanoemulgels represent a fascinating blend In recent years, the field of pharmaceutical sciences has witnessed remarkable advancements in drug delivery systems. Among these, the development of emulgels, microemulgels, nanoemulgels, niosomes, and exosomes has opened new horizons for effective and targeted drug delivery. This book aims to provide a comprehensive overview of these innovative carrier systems, highlighting their potential applications, benefits, and future prospects. In the evolving landscape of pharmaceutical sciences, the formulation and delivery of poorly water-soluble drugs present significant Emulsifying Drug challenges. Delivery Self- Systems (SEDDS) have emerged as a promising solution to enhance the bioavailability of these drugs. This innovative approach leverages the unique properties of self- emulsifying formulations to facilitate the absorption and efficacy of therapeutic compounds. This document aims to provide a comprehensive overview of SEDDS, exploring their mechanisms, formulation strategies, and potential applications in modern medicine. By delving into the intricacies of SEDDS, we aspire to shed light on their transformative potential and the future directions of drug delivery research. of emulsions and gels, combining the advantages of both systems. These formulations offer improved bioavailability, controlled release, and enhanced stability, making them suitable for various therapeutic applications. In this book, we delve into the formulation, characterization, and evaluation of these emulgel-based systems, providing insights into their unique properties and potential uses. Niosomes, another cutting-edge carrier system, have garnered significant attention due to their ability to encapsulate both hydrophilic and lipophilic drugs. As non- ionic surfactant vesicles, niosomes offer advantages such as biocompatibility, improved drug stability, and controlled release. We explore the formulation techniques, physicochemical properties, and therapeutic applications of niosomes, showcasing their versatility and efficacy. The secretome, particularly in the form of exosomes, has emerged as a promising cell-free carrier system. Exosomes, nanometer-sized extracellular vesicles, play a crucial role in intercellular communication and hold immense potential for drug delivery and regenerative medicine. This book provides an in-depth analysis of the secretome, focusing on the isolation, characterization, and therapeutic applications of exosomes, highlighting their innovation in the field of drug delivery role as natural and efficient drug carriers. Through a detailed exploration of these advanced carrier systems, this book aims to bridge the gap between research and clinical practice, offering valuable insights for scientists, researchers, and healthcare professionals. The chapters presented here are authored by leading experts in the field, ensuring a thorough and up-to-date understanding of the topics covered. We hope this book serves as a valuable resource, inspiring further research and systems. As we continue to unravel the potential of self-emulsifying drug delivery systems, emulgels, niosomes, secrotome and exosomes, we move closer to realizing more effective, targeted, and personalized therapies for a wide range of diseases. Sincerely, İzmir, Türkiye Prof. Dr. Emel Öykü Çetin Uyanıkgil 02.07.2024