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′The 4th edition of this extensive text is an outstanding resource prepared by nurses (and a librarian) for nurses. In a structured and helpful style it presents thousands of items from the literature - published papers, reports, books and electronic resources - as a clear, accessible, and most of all useful collection. The efforts to signpost and lead the reader to the sought-for information are effective and well-conceived, and the "How to use this book" section is remarkably simple...the book should be found in every nursing and health library, every research institute and centre, and close to many career researchers′ desks′ - RCN Research This latest edition of Resources for Nursing Research provides a comprehensive bibliography of sources on nursing research, and includes references for books, journal papers and Internet resources. Designed to act as a ′signpost′ to available literature in the area, this Fourth Edition covers the disciplines of nursing, health care and the social sciences. Entries are concise, informative and accessible, and are arranged under three main sections: · ′Sources of Literature′ covers the process of literature searching, including using libraries and other tools for accessing literature · ′Methods of Inquiry′ includes an introduction to research, how to conceptualize and design nursing and health research, measurement and data collection, and the interpretation and presentation of data · ′The Background to Research in Nursing′ encompasses the development of nursing research; the profession′s responsibilities; the role of government; funding; research roles and careers; and education for research. Fully revised and updated, the Fourth Edition includes just under 3000 entries, of which 90% are new. It has extensive coverage of US, UK literature and other international resources. This new edition will be an essential guide for all those with an interest in nursing research, including students, teachers, librarians, practitioners and researchers.

Theileria equi (T. equi) is one of the causative agents of equine piroplasmosis, a severe tick-transmitted disease that affects most equid species. Control of the parasite is impeded by the lack of an effective vaccine and the fact that it can be transmitted by multiple tick vectors. T. equi is classified within the phylum Apicomplexa due to the presence of secretory organelles (micronemes, rhoptries and dense granules) on the apical end of the parasite that are essential for invasion and establishment of apicomplexans within host cells. Unlike most apicomplexan species, the roles of these organelles, and their contents in host cell invasion remain unexplored in T. equi. In chapter one, we evaluate the role of T. equi micronemes by assessing the role of the claudin like apicomplexan microneme protein (CLAMP) in erythrocyte invasion and identify equine erythrocyte components that interact with the protein during cell entry. We also assess expression of CLAMP in the merozoite and intra-erythrocytic developmental stages of T. equi and evaluate its immunogenicity as a potential vaccine candidate. The results show that the protein is expressed in both developmental stages and elicits significant antibody responses in horses during T. equi infection, indicating that it is a viable candidate for vaccine development. The results also show that CLAMP is involved in invasion of equine erythrocytes and the protein interacts with key components of the equine erythrocyte cytoskeleton during cell entry. In chapter two, we evaluate the role of T. equi rhoptries in invasion. In this regard, we assess the expression of the rhoptry associated protein-1a and -1b (RAP-1a and RAP-1b) in the merozoite and intra-erythrocytic developmental stages of T. equi and evaluate their immunogenicity and roles in invasion. Our findings show that both proteins are expressed in both developmental stages and while RAP-1a is highly immunogenic and involved in erythrocyte entry, the N- and C-termini of RAP-1b are not required for cell entry and are not immunogenic. In conclusion, our findings show that like most apicomplexan species, the T. equi secretory organelles are involved in invasion and their contents can be targeted for vaccine development.