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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Principles of Adaptive Optics describes the foundations, principles, and applications of adaptive optics (AO) and its enabling technologies. This leading textbook addresses the fundamentals of AO at the core of astronomy, high-energy lasers, biomedical imaging, and optical communications. Key Features: Numerous examples to explain and support the underlying principles Hundreds of new references to support the topics that are addressed End-of-chapter questions and exercises A complete system design example threaded through each chapter as new material is introduced

PCM Enhanced Building Envelopes presents the latest research in the field of thermal energy storage technologies that can be applied to solar heating and cooling with the aim of shifting and reducing building energy demand. It discusses both practical and technical issues, as well as the advantages of using common phase change materials (PCMs) in buildings as a more efficient, novel solution for passive solar heating/cooling strategies. The book includes qualitative and quantitative descriptions of the science, technology and practices of PCM-based building envelopes, and reflects recent trends by placing emphasis on energy storage solutions within building walls, floors, ceilings, façades, windows, and shading devices. With the aim of assessing buildings’ energy performance, the book provides advanced modeling and simulation tools as a theoretical basis for the analysis of PCM-based building envelopes in terms of heat storage and transfer. This book will be of interest to all those dealing with building energy analysis such as researchers, academics, students and professionals in the fields of mechanical and civil engineering and architectural design

This widely acclaimed book is a complete, authoritative reference on nutrition and its role in contemporary medicine, dietetics, nursing, public health, and public policy. Distinguished international experts provide in-depth information on historical landmarks in nutrition, specific dietary components, nutrition in integrated biologic systems, nutritional assessment through the life cycle, nutrition in various clinical disorders, and public health and policy issues. Modern Nutrition in Health and Disease, Eleventh Edition, offers coverage of nutrition's role in disease prevention, international nutrition issues, public health concerns, the role of obesity in a variety of chronic illnesses, genetics as it applies to nutrition, and areas of major scientific progress relating nutrition to disease.

90 World Classics You Should Read Before You Die (Vol.2) encapsulates an extraordinary collection of seminal works that span genres, centuries, and continents, offering readers a panoramic view of global literary achievements. This anthology brings together an unparalleled array of literary styles, ranging from the foundational texts of Western literature to transformative stories from Eastern philosophies, underlining the rich tapestry of human experience and creativity. Among the collection's highlights are seminal works that have shaped and transcended their cultural and historical periods, inviting readers to explore the depths of human consciousness, the complexities of social orders, and the transcendent beauty of the world around us. The contributing authors and editors, from Goethe and Dickens to Tagore and Woolf, represent the pinnacle of literary achievement in their respective fields and epochs. This collection not only celebrates the monumental achievements of these literary figures but also illustrates the diverse cultural, historical, and philosophical underpinnings that have informed their writing. The anthology aligns with and contributes to a multiplicity of literary movements, from Romanticism to Realism, Modernism to the Enlightenment, showcasing the evolving nature of humanity's storytelling prowess and its enduring quest to understand the human condition. 90 World Classics You Should Read Before You Die (Vol.2) is recommended for readers who seek to immerse themselves in the rich diversity of global literature. This collection offers a unique opportunity to engage with the thoughts, dreams, and narratives of some of the most celebrated authors in history, providing a broad spectrum of insights, styles, and themes within a single volume. For educators, students, and avid readers alike, this anthology is an invaluable resource for expanding one's literary horizons, fostering a deeper appreciation for the art of storytelling, and engaging in the dialogues that have shaped our world.

90 Masterpieces You Must Read (Vol.2) stands as a monumental anthology that bridges the expanses of literary history, style, and thematic depth, bringing together an extraordinary collection of works that have shaped and reflected the human condition across centuries. This volume is intricately curated to showcase the diversity of literary expression, ranging from the epic poetry of Homer to the existential musings of Friedrich Nietzsche, the nuanced social realities captured by Jane Austen to the speculative visions of H. G. Wells. Standout pieces within this collection underscore the anthology's capacity to offer insights into the complexities of love, the struggles for identity, and the ceaseless quest for meaning amidst societal upheaval. The anthology also highlights key movements in literary history, providing readers with a panoramic view of the evolution of narrative form and thematic exploration. The authors and editors represented in this collection bring a rich mosaic of cultural, historical, and personal backgrounds to the theme of the anthology. From the philosophical discourses of Confucius and Laozi to the pioneering feminist narratives of Charlotte Perkins Gilman and Kate Chopin, these works collectively offer a multifaceted examination of human society, thought, and emotion. The anthology does not merely present a historical cross-section of literary movements; rather, it weaves together the Enlightenment's rationalism, Romanticism's glorification of emotion, the biting critique of Realism, and the introspective depth of Modernism, among others. This convergence of diverse voices serves to enrich the reader's understanding of the overarching themes, underscoring the universality of human experience across time and place. 90 Masterpieces You Must Read (Vol.2) is an essential addition to the library of any scholar, student, or enthusiast of literature. It offers a unique opportunity to immerse oneself in a range of literary styles, themes, and historical contexts, all within a single volume. For those seeking to broaden their literary horizons or deepen their understanding of the mosaic of human experience as expressed through literature, this collection serves as a gateway to the myriad ways in which storytelling has captured the essence of being. The anthology invites readers to engage in a dialogue with the past, to reflect on the present, and to ponder the future through the enduring power of written word.

This book highlights the role of point-of-care (POC) testing in the effective management of the coronavirus disease 2019 (COVID-19) pandemic with an in-depth focus on the recent developments in the field, existing gaps, and future directions. POC tests are of utmost importance as they facilitate rapid and decentralized testing without much instrumentation and technical expertise. The book describes the current status of POC COVID-19 testing in three broad categories: Molecular, antigen, and antibody. The advantages, limitations, and adaption of each of the POC tests are reviewed while highlighting their clinical impact in real-world settings. The role of POC testing for COVID-19 screening, diagnosis, and surveillance has been emphasized. The subtle difference between POC and at-home tests is discussed while elaborating on the necessity for the latter for enhancing clinical impacts. A spotlight on the influence of variants on the performance of POC-COVID-19 tests is provided. The consideration of clinical implications of POC testing in hospitals with regards to improving therapeutic options, patient flow, enhancing the infection control measures, and early recruitment of patients into clinical trials is explained. Finally, the future perspectives that will aid the research community in the development of POC tests for COVID-19 or any infectious disease, in general, are presented. Overall, we believe this book can benefit the research community as it (i) presents a comprehensive understanding of current COVID-19 POC testing methods (ii) highlights features required to transform the current tests developed during the past year as POC diagnostics, and (iii) provides insights to address the unmet challenges in the field.

This widely acclaimed book is a complete, authoritative reference on nutrition and its role in contemporary medicine, dietetics, nursing, public health, and public policy. Distinguished international experts provide in-depth information on historical landmarks in nutrition, specific dietary components, nutrition in integrated biologic systems, nutritional assessment through the life cycle, nutrition in various clinical disorders, and public health and policy issues. Modern Nutrition in Health and Disease, Eleventh Edition, offers coverage of nutrition's role in disease prevention, international nutrition issues, public health concerns, the role of obesity in a variety of chronic illnesses, genetics as it applies to nutrition, and areas of major scientific progress relating nutrition to disease.

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.