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This practical, concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved.

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. - Highlights the latest developments in the field in a concise volume - Provides details of key fluorinating reagents across diverse families of organic compounds - Explores the current applications and future potential of fluorine in drug development

Sustainable History and the Dignity of Man is a new philosophy of history. This volume outlines how sustainable history is propelled by good governance, which balances the tension between the attributes of human nature - emotionality, amorality and egoisms - and human dignity needs, such as reason, security, human rights, accountability, transparency, justice, opportunity, innovation and inclusiveness. The author proposes minimum criteria for good governance that are sensitive to local cultures and histories but meet certain common global values to ensure maximum and sustainable moral and political cooperation. Using an ocean model of a single collective human civilisation, the author argues that we should think in terms of a common human story that is comprised of multiple geo-cultural domains and sub-cultures with a history of mutual borrowing and synergies. The author argues that, today, all geo-cultural domains must succeed if humanity as a whole is to triumph. This collective triumph will also depend on reason and a recognition that a great deal of knowledge is indeterminate and may be temporally, spatially and perhaps culturally constrained, as is outlined in the author's new theory of knowledge: "Neuro-rational Physicalism". Dr. Nayef R.F. Al-Rodhan is Senior Scholar in Geostrategy and Director of the Programme on the Geopolitical Implications of Globalisation and Transnational Security at the Geneva Centre for Security Policy, Geneva, Switzerland. "This book is an exceptionally wide-ranging examination of past and present approaches to the securing of a qualitatively adequate social life on the planet. The need for intercultural dialogue is pressing and stated as a matter of urgency in the text. That argument is well-presented and it is helpfully accompanied by a large amount of empirical evidence. The book is also a strong and ethically attractive humanist statement about the value of human interaction that incorporates a vision of mutual respect based on a mixture of scientific arguments and normative aspirations. Those features are very impressive." Professor Michael Freeden, Professor of Politics, Director of the Centre for Political Ideologies, Professorial Fellow, Mansfield College, University of Oxford, United Kingdom.

This practical, concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved.

Pode o amor mudar o curso da Historia? Bin Rahhal, o braco-direito do vizir do Bahrein, era um homem particularmente atraente - e o seu olhar, misterioso e intenso, parecia mergulhar na propria alma. Halima era uma jovem mulher de uma beleza excecional. Alta e esbelta, de olhos brilhantes e longos cabelos negros, uma princesa de Ormuz. Quando os olhos de ambos se cruzaram, Bin Rahhal ficou enfeiticado. O rosto da princesa gravou-se na sua mente, e desde ent?o ela nunca mais lhe saiu do pensamento. Mas Halima, ponderada, tentou resistir aquele estranho, de outras terras. Na Arabia vivem-se tempos de incerteza. Cada vez mais, ouvem-se os rumores de avistamentos de navios com as velas brancas com a Cruz de Cristo. A chegada dos portugueses ao Oriente, que p?e em evidencia as diferencas culturais, ameaca por fim ao modo de vida arabe e mudara de forma drastica a historia de amor entre Bin Rahhal e Halima.

Escrita en árabe hacia 1637, combinando autobiografía con crónica de viajes, esta obra de indudable valor histórico y cultural relata, con un rigor no exento de humor, vivencias de un autor polifacético, cuya trayectoria no es la de un morisco cualquiera. Anticipando el destierro de los moriscos en 1609, Afocay al-Ḥaŷarí, alias Diego Bejarano, sale de España clandestinamente hacia 1599 y se exilia en Marruecos, país en el que pasa casi cuarenta años, ejerciendo de secretario intérprete para tres sultanes, antes de acabar sus días en Túnez. Atento en todo momento a la causa de su comunidad en el exilio, el autor narra sus andanzas por España, Mazagán, Marruecos, Francia, Flandes, Egipto, Meca, Túnez, etc., reproduciendo escenas de fe, aventura, romance y milagro en las que se ve involucrado y que son intercaladas por anécdotas curiosas, testimonios impactantes y reflexiones apasionantes sobre temas variados, desde la cristianización, persecución y posterior destierro de los andalusíes o la repercusión del fenómeno de los libros plúmbeos en Granada hasta la posición geopolítica de España en el mundo, la situación política y social en Marruecos y el Magreb, la vida en países como Flandes y Francia o el papel del imperio otomano en la cuenca del Mediterráneo, pasando por contactos mantenidos con grandes ulemas, altas autoridades en Flandes y Francia o los primeros orientalistas holandeses y franceses y disputas teológicas habidas con interlocutores cristianos y judíos.