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This Christian formation text combines insights from social science, biblical studies, and ethics to present a dynamic vision of human holiness and wholeness.

Thirty-year-old Sidney Green Stone has just found out that her childhood love Jonathan Knight is missing and presumed dead. She has married a man she is not sure she loves, ignores a drunken father that she can't deal with, refuses to mention a mother that committed suicide, and dismisses a sister and a lifelong friend, all to escape her childhood spent in a small southern town that she feels has brought her nothing but misery. Sidney is starting to question her marriage, her family, and ultimately herself, apparently just as her deceased mother Hope did at the same age, right before she committed suicide on her thirtieth birthday. On some level between heaven and earth, Jonathan is sent by Sidney's mother to communicate with Sidney through her dreams, in an attempt to help Sidney rediscover who she is, and learn how to love herself, her family, and her life. This is a story about listening to your dreams, and learning from them how to forgive, hope, and love again.

Esta edición en español corresponde a la segunda edición en inglés del Diccionario de Jesús y los Evangelios. Es una versión completamente reconstruida y revisada de la aclamada primera edición en 1992. Desde la publicación de ese volumen innovador, una ola de nuevos descubrimientos y escritos académicos y de investigación han aparecido a orillas de este nuevo siglo muchos de los cuales están documntados en este tomo. Obra de referencia, independiente de la información y la perspectiva esencial para explorar sobre Jesús y los Evangelios. En este volumen se unen dos áreas y perspectivas: la de los académicos y la de los pastores, maestros, estudiantes y lectores interesados que desean estudios profundos de los temas claves, en un formato accesible y resumido. Los artículos cubren cada Evangelio, los episodios principales de la vida de Jesús, los temas transcendentales, así como los problemas y métodos de interpretación. El Diccionario de Jesús y los Evangelios es un compañero indispensable para el estudio y la investigación. Es la puerta de entrada a un resumen fiable y completo y a una evaluación de los últimos veinte años de investigación sobre Jesús. Una nueva generación de estudiosos ha abierto el camino para el siglo XXI. • Proporciona una obra de referencia fundamental para el estudio de Jesús y los Evangelios • Incluye artículos sobre los Evangelios, los episodios y los temas • Cubre los aspectos de Jesús y el estudio del Jesús histórico • Cubre el origen judío, helenístico y romano • Incluye bibliografías actualizadas y amplias • Incluye estudios de métodos de estudio de Jesús y los Evangelios • Cuenta con 175 artículos de fondo • Más del noventa por ciento de los artículos son escritos recientes • Escrito por cerca de 100 colaboradores expertos

Provides a current listing of materials on individuals with disabilities, many written since 1982 and currently in print, both fiction and nonfiction, for children from preschool through adolescence. Cf. p. ix.

Abstract: Glioblastomas are highly malignant brain tumors that derive from brain-tumor-initiating cells (BTICs) and can be subdivided into several molecular subtypes. Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic agent. The effects of metformin on glucose metabolism have been extensively studied, but there are only few data on amino acid metabolism. We investigated the basic amino acid profiles of proneural and mesenchymal BTICs to explore a potential distinct utilization and biosynthesis in these subgroups. We further measured extracellular amino acid concentrations of different BTICs at baseline and after treatment with metformin. Effects of metformin on apoptosis and autophagy were determined using Western Blot, annexin V/7-AAD FACS-analyses and a vector containing the human LC3B gene fused to green fluorescent protein. The effects of metformin on BTICs were challenged in an orthotopic BTIC model. The investigated proneural BTICs showed increased activity of the serine and glycine pathway, whereas mesenchymal BTICs in our study preferably metabolized aspartate and glutamate. Metformin treatment led to increased autophagy and strong inhibition of carbon flux from glucose to amino acids in all subtypes. However, oral treatment with metformin at tolerable doses did not significantly inhibit tumor growth in vivo. In conclusion, we found distinct amino acid profiles of proneural and mesenchymal BTICs, and inhibitory effects of metformin on BTICs in vitro. However, further studies are warranted to better understand potential resistance mechanisms against metformin in vivo