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Lara pasa las vacaciones en Atenas para visitar a su padre, que se encuentra en la ciudad griega trabajando en una excavación. Haciendo turismo, Lara entra en una tienda de antigüedades en la que un misterioso anciano le regala un brazalete. Ese brazalete conectará a Lara con uno de los secretos mejor guardados de la humanidad, el de la poderosa espada con la que luchó Alejandro Magno y con Elisa, una de las sacerdotisas de Atenea en la antigua Grecia.

Approximately 20% to 40% of clinically defined familial hypercholesterolemia (FH) cases do not show a causative mutation in candidate genes (mutation-negative FH), and some of them may have a polygenic origin.The aim of this work was to study the association of SNVs in APOB, APOE, LDLR, NR5A2, PCSK9, PPARGC1A and SREBF2 genes in mutation-negative FH, with hepatic synthesis of cholesterol (desmosterol concentrations) and thus studied variants could explain in part the mechanism of hypercholesterolemia.We studied 40 SNVs in APOB, APOE, LDLR, NR5A2, PCSK9, PPARGC1A and SREBF2 genes in 200 mutation-negative FH and 96 controls. Surrogate markers of cholesterol hepatic synthesis (desmosterol and lanosterol) were quantified by high-performance liquid chromatography-tandem mass spectrometry in both studied groups.We observed significantly higher concentration of desmosterol in mutation-negative FH than in controls (p