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Born in a provincial city in the Peruvian Andes, the Franciscan linguist and theologian Luis Gerónimo de Oré (1554–1630) lived during a critical period in the formation of the modern world, as the global empire of Spain engaged in a nearly continuous struggle over resources and religion. In the first full-length biography of Oré, Noble David Cook and Alexandra Parma Cook reconstruct the friar’s life and the communities in which he circulated, tracing the career of this first-generation Creole from his roots in Huamanga to his work in Andean missions, his activities at the royal courts of Spain and throughout Spanish America, until his final years as bishop of Concepción, Chile. While serving in Peru’s Colca Valley, Oré composed multilingual texts, translating doctrinal concepts into the indigenous languages Quechua and Aymara, alongside Latin and Spanish, which missionaries and secular clergy frequently used in their conversion efforts. As commissioner to Cuba and La Florida, he inspected the frontier missions along the coast of what became the southeastern United States and wrote an influential history of these outposts and their environment. After Philip III dispatched him to Concepción, Oré spent his last years working in the southernmost end of the Americas, where he continued his advocacy for indigenous justice and engaged in heated arguments with the governor over defensive war, royal patronage, and Indian enslavement. Drawn from research conducted in Spain and Latin America over several decades, this consequential biography recovers from obscurity a colonial friar whose legacy continues in the Andean world today.

Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.* Thousands of literature references provide introduction to current research as well as historical background* Contains twice the number of chapters of the first edition* Each chapter contains boxes of information on topics of general interest

Poets extol the burst of aroma when the bottle is opened, the wine poured, the flavor on the palate as it combines with the olfactory expression detected and the resulting glow realized. But what is the chemistry behind it? What are the compounds involved and how do they work their wonder? What do we know? Distinct and measurable differences in terroir, coupled with the plasticity of the grape berry genome and the metabolic products, as well as the work of the vintner, are critical to the production of the symphony of flavors found in the final bottled product. Analytical chemistry can inform us about the chemical differences and similarities in the grape berry constituents with which we start and what is happening to those and other constituents as the grape matures. The details of the grape and its treatment produce substantive detectable differences in each wine. While there are clear generalities - all wine is mostly water, ethanol is usually between 10% - 20% of the volume, etc - it is the details, shown to us by Analytical Chemistry and structural analysis accompanying it, that clearly allow one wine to be distinguished from another.

Continuing the mission of the first two editions, Food Emulsions: Principles, Practices, and Techniques, Third Edition covers the fundamentals of emulsion science and demonstrates how this knowledge can be applied to control the appearance, stability, and texture of emulsion-based foods. Initially developed to fill the need for a single resource co

En este número, continúa el análisis de Jorge Manzano sobre las objeciones que varios filósofos hacen a la crítica de Bergson sobre la idea de la nada. Asimismo, se incluyen las intervenciones en una mesa redonda de tres académicos de gran categoría: Francisco Xavier Garciadiego, que habla del contexto y proceso históricos que se dieron para la creación de El Colegio de México; José Sarukhán Kermez, que introduce a la estructura y los organismos constituidos para el funcionamiento de una institución de grandes proporciones, como la UNAM, y Antonio Lazcano, quien expone los principales modelos de universidad que se han ido gestando desde la Edad Media. Por su parte, Luis García Orso describe la experiencia de profundo desconcierto ante la violencia en nuestro país que Everardo González plasma en La libertad del diablo. Y para cerrar, se presenta un texto coordinado por David Velasco sobre las acciones poco conocidas de defensores de derechos humanos para el respeto de los derechos humanos en México. (ITESO) (Xipe totek)

This book presents state-of-the-art, accessible reviews of the science of alcohol treatment and guidance for the management of clinical situations.

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

The largest seaweed, giant kelp (Macrocystis) is the fastest growing and most prolific of all plants found on earth. Growing from the seafloor and extending along the ocean surface in lush canopies, giant kelp provides an extensive vertical habitat in a largely two-dimensional seascape. It is the foundation for one of the most species-rich, productive, and widely distributed ecological communities in the world. Schiel and FosterÕs scholarly review and synthesisÊtake the reader from DarwinÕs early observations to contemporary research, providing a historical perspective for the modern understanding of giant kelp evolution, biogeography, biology, and physiology. The authors furnish a comprehensive discussion of kelp species and forest ecology worldwide, with considerations of human uses and abuses, management and conservation, and the current and likely future impacts of global change. This volume promises to be the definitive treatise and reference on giant kelp and its forests for many years, and it will appeal to marine scientists and others who want a better appreciation and understanding of these wondrous forests of the sea.