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The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

Due to the growing population of dry eye patients, there has been much study of dry eye disease. Following the full reports of the International Dry Eye Workshops of 2007 and 2017 (DEWS I and II), as well as the recent Dry Eye Assessment and Management (DREAM) trial, there is a growing body of consensus and evidence-based literature on the treatment of dry eye. Dry Eye Disease: A Practical Guide synthesizes all these scientific sources into a comprehensive, yet, user-friendly clinical reference. From epidemiology and pathogenesis, to disease subgroups, diagnostics, and management, Drs. Francis Mah and Michelle Rhee with their team of over 35 renowned contributors have distilled all the latest information on dry eye disease into an easily digestible guide. Featuring diverse case scenarios pulled from clinical practice, Dry Eye Disease engages the reader and encourages critical thinking to apply current understanding of dry eye disease to the office and operating room. All aspects of this complex disease are discussed, including the relationship between dry eye and surgical outcomes and contact lens wear. Some topics include: The latest biomarker diagnostics Meibomian gland dysfunction therapeutic technologies The role of integrative medicine Advances in therapeutic contact lenses Ophthalmologists and optometrists of all specialties and skill levels will find Dry Eye Disease: A Practical Guide a comprehensive yet practical clinical guide for treating the growing population of dry eye patients.

Myalgic encephalomyelitis, also known as Chronic Fatigue Syndrome, is a deeply complex and multi-system condition which has historically suffered from a lack of awareness within physiotherapy education and practice. Similarities in presentation between this condition and Long Covid make this comprehensive and evidence-based guide for physiotherapists even more timely and important. This guide includes an in-depth explanation and history of ME/CFS whilst also describing symptoms, varying degrees of severity, and how to manage ME/CFS in children. It also provides detailed management advice and discussion on how the information can directly inform physiotherapy practice, supplemented with patient case studies.

Experience the hardships and tribulations of a Chinese family living in poverty prior to World War II. Our resource acts as a great supplement to the novel in order to help students comprehend it deeper. Set the tone by brainstorming the traditional ways people celebrate the birth of babies. Analyze the actions of Wang Lung's uncle to describe his true character. Identify what is being described from the metaphors and similes in the text. Understand key vocabulary words prior to reading with fill-in-the-blank paragraphs. Research the meaning of each form of literary irony, then identify the type of irony used in the novel. Write a sensory poem to express the many representations of the land to Wang Lung. Aligned to your State Standards and written to Bloom's Taxonomy, additional crossword, word search, comprehension quiz and answer key are also included. About the Novel: The Good Earth is a Pulitzer Prize-winning story about family life in a Chinese village before World War II. Wang Lung and his new wife O-Lan buy land from the Hwang family in the hopes of starting a modest farm. During this time, O-Lan gives birth to three sons and three daughters. The first daughter becomes mentally handicapped due to severe malnutrition and famine, causing O-Lan to kill the second daughter and sell the third to a merchant. Famine and drought force the family to leave for a large city in the South to find work. Arriving in the city, Wang Lung finds a job pulling a rickshaw, while his family turns to begging. Things get better when armies approach the city and a food riot erupts. Wang Lung receives enough money to return home and have a prosperous life.

From wired campuses to smart classrooms to massive open online courses (MOOCs), digital technology is now firmly embedded in higher education. But the dizzying pace of innovation, combined with a dearth of evidence on the effectiveness of new tools and programs, challenges educators to articulate how technology can best fit into the learning experience. Minds Online is a concise, nontechnical guide for academic leaders and instructors who seek to advance learning in this changing environment, through a sound scientific understanding of how the human brain assimilates knowledge. Drawing on the latest findings from neuroscience and cognitive psychology, Michelle Miller explores how attention, memory, and higher thought processes such as critical thinking and analytical reasoning can be enhanced through technology-aided approaches. The techniques she describes promote retention of course material through frequent low‐stakes testing and practice, and help prevent counterproductive cramming by encouraging better spacing of study. Online activities also help students become more adept with cognitive aids, such as analogies, that allow them to apply learning across situations and disciplines. Miller guides instructors through the process of creating a syllabus for a cognitively optimized, fully online course. She presents innovative ideas for how to use multimedia effectively, how to take advantage of learners’ existing knowledge, and how to motivate students to do their best work and complete the course. For a generation born into the Internet age, educational technology designed with the brain in mind offers a natural pathway to the pleasures and rewards of deep learning.

Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.

The phospholipid, phosphoinositol 4, 5, bisphosphate (PIP2) has been implicated in a number of diverse cellular functions, which include membrane trafficking, regulation of the actin cytoskeleton, endocytosis and exocytosis. However, the mechanism for regulation of PIP2 within the cell during these functions is unknown. One hypothesis for regulation involves controlling the lateral distribution and accessibility of PIP2 within the membrane, possibly through interactions with proteins or lipid domains. A spin labeled derivative of PIP2 (proxyl-PIP2) was synthesized and characterized through electron paramagnetic resonance (EPR) spectroscopy. The proxyl-PIP2 is soluble in chloroform and incorporates into lipid vesicles with the proxyl label resting at the membrane interface. Upon addition of known PIP2 binding molecules such as neomycin and the PLC delta 1 PH domain, the EPR spectrum of proxyl-PIP2 shows an increased linewidth, indicative of a decrease in label motion. Furthermore, the proxyl-PIP2 shows a 1:1 binding upon titration with neomycin, with the same association documented for native PIP2 affinities. Therefore, the proxyl-PIP2 can be used as a probe to investigate and quantitate PIP2 interactions within the membrane bilayer. This probe can also be used to distinguish lateral lipid domains enriched in PIP2. MARCKS is a 87 kDalton protein that contains a highly basic region called the effector domain. The effector domain of the protein is the site phosphorylated by PKC, it binds to calmodulin and helps associate MARCKS to the lipid membrane through electrostatic and hydrophobic interactions. MARCKS binds strongly to PIP2 and may function in a regulatory role by sequestering this lipid. Upon the addition of a peptide from the MARCKS effector domain the proxyl-PIP2 EPR spectrum exhibits changes in linewidth due to a decrease in motional averaging, as well as spin-spin interactions resulting from the close proximity of several proxyl-PIP2.

Hydrogen Fuel for Surface Transportation provides background information on the advantages and disadvantages of hydrogen as a fuel, describes the current state of technology of hydrogen-fueled vehicles, and discusses the future requirements of the "hydrogen economy." Each chapter also includes reprints of noteworthy articles and technical papers on the subject.