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Methylglyoxal (MG), a highly reactive dicarbonyl accumulates after myocardial infarction (MI), causing adverse remodelling and cardiac dysfunction. We hypothesized that therapy using bone marrow cells (BMCs) overexpressing glyoxalase1 (Glo1), the main enzyme that metabolizes MG, injected into mouse MI model would translate into better survival of transplanted cells and improve their therapeutic effect. We found that Glo1 expression is significantly reduced at 7 days post-MI. Glo1 BMCs exposed to MG in vitro displayed greater angiogenic potential and reduced reactive oxygen species production compared to wild type (WT) BMCs. However, in the mouse MI model, Glo1 BMCs did not improve cardiac function or vascularity or reduce scar formation compared to WT BMCs and saline treatments. In conclusion, Glo1 overexpression in BMCs does not confer superior therapeutic efficacy for treating MI under the conditions tested.

Jair Bolsonaro was the President of Brazil from 2019-2022. During the course of his presidency, he reduced Indigenous people's rights over land by dismantling health and environmental policies. I propose the Bolsonaro effect as an increase in state violence against Indigenous people as the outcome of the following: the furthering of economic ventures aimed at extracting natural resources from the Amazon (home of most Indigenous communities in Brazil); invasions on Indigenous territories increasing as a result of the economic initiatives in the tropical forest due to the Bolsonaro administration's negligent actions to prevent targeted violence from occurring. The failure of the Brazilian State to protect Indigenous people was demonstrated once more during the global pandemic of 2020. I use forest fires and the COVID19-pandemic as my case studies to analyze Bolsonaro's political narratives and executive decisions against Indigenous people. By the end of his term in office, Bolsonaro was accused of human rights violations.

[A] documentary photo-book that recounts and describes - through photographs taken by Padula himself 30 years ago - [his experiences] learning about the life of the Yanomami indigenous people, during a trip through the Upper Orinoco.

Our starting point is the COP16 Accord, which states that: “developed country Parties commit, in the con- text of meaningful mitigation actions and transparency on implementation, to a goal of mobilizing jointly USD 100 billion per year by 2020 to address the needs of developing countries”. The world needs to simultaneously tackle the COVID-19 and climate crises. The pandemic has highlighted that the old normal was deeply fragile and dangerous. Should the world fail to act now, the harm caused by climate change and biodiversity loss will be much greater and longer-lasting than the damage inflicted by COVID-19. The immediate imperative in recovery is to “build back better”, placing the world on a path of sustainable, inclusive, and resilient growth. The crisis presents an enormous threat but also a one-off, last-chance opportunity – to restructure econ- omies at the pace and scale that climate science requires by integrating climate action into the economic recovery from COVID-19. If EMDEs are unable to put in place recovery packages that are strong and sustainable, it will not only be deeply damaging for their own growth prospects but will put the climate goals irrevocably beyond reach. EMDEs already account for two-thirds of global emissions and many are also the most vulnerable in the face of climate change. A strong program of support to tackle their debt and financing needs is a win-win proposition for the global economy and for the climate.

Effects of Growth Hormone (GH) Overexpression in Signaling Cascades Involved in Promotion of Cell Proliferation and Survival.

This book aims to provide readers with a general as well as an advanced overview of the key trends in endocrine disorders. While covering a variety of topics ranging from thyroid carcinogenesis and pituitary adenomas to adrenal tumors and metabolic bone disease, this book also focuses on more specific issues not yet fully elucidated (e.g. the molecular pathways involved in thyrotropin beta gene regulation or monogenic phosphate balance disorders). Readers of different fields and background will have the opportunity to update their knowledge and more importantly to clarify areas of uncertainty and controversies in several topics of endocrine disorders.

Descubre la mágica historia de Zoe, una niña que vive la fascinante experiencia de la caída de los dientes. Este cuento transporta a los lectores al mundo de los sueños infantiles, revelando las emociones únicas que acompañan a este encantador momento. Acompaña a Zoe en su emocionante aventura, donde la maravillosa magia se entrelaza con sus sueños, creando un universo lleno de sorpresas. Este relato invita a explorar la magia que reside en cada niño y a recordar la importancia de soñar junto a ellos. No te pierdas esta entrañable historia que celebra la maravilla de la infancia.

This study attempts to identify and assess policy options for the EU to achieve cyber-resilience, and to develop capabilities, and industrial and technological resources for a trustworthy EU cyberspace, with a view also to promoting core values, such as online privacy protection. The findings could form the basis for an assessment of alternative measures to improve the resilience of the European ICT industry and the EU's strategic decision-making capacity, and enhance the resilience of critical information technology networks. The study further reviews the current state of reciprocity between search engine services and individual customers. The ultimate aim of this study is to develop concrete policy options to be considered by EU institutions and Member States - and potentially to be used as background by EP committees for their legislative and own-initiative reports.