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The specific mechanisms involved in the replication and gene expression of a number of viruses have been under investigation for many years. At present, significant breakthroughs to the field of virology in general have led to a more complete understanding of virus replication as well as the interactions between viruses and their hosts during the infection process. One of the more recent and prominent outcomes of this accumulation of knowledge has been the ability of viruses from many origins to be engineered and developed for use as expression vectors. Virus expression vectors can be developed for a wide variety of purposes ranging from gene therapy delivery systems to vaccine production systems or even to novel protein production systems for applications in industry. This book contains the accumulative effort of an array of leading international scientists who have worked toward developing virus expression vectors for these and other purposes. The development of animal, plant and insect viruses as expression vector systems has been included. Each chapter contains a literature review and highlights more recent developments within the authors' laboratories with respect to areas such as research in virus vector development, virus replication, or specific virus-host cell interactions. A number of these studies have now left the laboratory bench and are at the stage of preliminary clinical trials or, as in the case of plant virus expression vectors, field trials. This book is dedicated to my father Dennis C. Hefferon, who is a lawyer and academic, not a virologist, but nonetheless provided the inspiration for creating Virus Expression Vectors.

This study sought to determine if HIV+ depressed men were more likely to be neuropsychologically impaired than their non-depressed counterparts. Subjects were 47 HIV+ men who met DSM-III-R criteria for Major Depression and 47 non-depressed controls (M̲ Age = 34.17) matched on HIV disease severity, demographics, and drug use. Subjects completed extensive psychiatric, neuropsychological, and medical assessments at baseline (N̲ = 94), and one year follow-up (n̲ = 44). Global neuropsychological impairment in the two groups did not differ at baseline, x2 (1, N = 94) = 2.11,p̲>.05, or at one year follow-up, x2 (1, N = 44) =.051, p̲>.05. While depressed subjects performed less well than non-depressed subjects on memory tests at baseline (memory portions of the Story Memory Test, F̲ (1, 87) = 5.34, p̲ =.01, and Figure Memory Test, F̲ (1, 79) = 4.16, p̲ =.02), the majority of depressed subjects (64%) were not impaired on Memory; and the groups did not differ significantly on any of the other major ability areas assessed. The results suggest that while HIV+ depressed subjects may perform more poorly on memory tasks, they are not likely to evidence clinically significant neurocognitive impairment

The focus of this nurse practitioner text is on 81 commonly seen disorders of adult women. It addresses both the medical aspects of the disorders and the nursing concerns and patient education.