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Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.

This volume provides an introduction to ancient Greek mythology through the theme of cosmogonies and theogonies --myths of origins that told the creation of the world and the birth and succession of the gods. Greek Mythology additionally features important foundational myths related to the early stages of humankind, such as the sequence of the Five Races, the first sacrifice, the creation of woman, and the Flood, all part of the core Greek myths about the beginnings of the world. The centerpiece of the volume is Hesiod's Theogony as well as parts of Works and Days which are, along with the Iliad and Odyssey, the earliest Greek literary texts preserved. The volume includes freshly translated excerpts from these canonical sources along with discussions of alternative cosmogonies and theogonies in the Greek tradition, in a rare feature for myth overviews. Beyond providing an overview of the central stories, Greek Mythology reveals myriad aspects of the myths, such as their literary form and performative contexts, their relationship to Near Eastern myths, their religious relevance and ritual function, and their reception, both in later antiquity and in modern times.

Situated in the South Texas borderlands some fifty miles west of Corpus Christi, San Diego was a thriving town already a hundred years old at the turn of the twentieth century. With a population that was 90 percent Mexican or Mexican American and 10 percent Anglo, the bicultural community was the seat of Duval County and a prosperous town of lumberyards, banks, mercantile stores, and cotton gins, which also supplied the needs of area ranchers and farmers. Though Anglos dominated its economic and political life, San Diego was culturally Mexican, and Mexican Americans as well as Anglos built successful businesses and made fortunes. This collection of nearly one hundred photographs from the estate of amateur photographer William Hoffman captures the cosmopolitan town of San Diego at a vibrant moment in its history between 1898 and 1909. Grouped into the categories women and their jobs, local homes, men and their businesses, children at school and church, families and friends, and entertainment about town, the photos offer an immediate visual understanding of the cultural and economic life of the community, enhanced by detailed captions that identify the subjects and circumstances of the photos. An introductory historical chapter constitutes the first published history of Duval County, which was one of the most important areas of South Texas in the early twentieth century.

This book examines sociolinguistic, educational and psycholinguistic factors that shape the path to sign bilingualism in deaf individuals and contributes to a better understanding of the specific characteristics of a type of bilingualism that is neither territorial nor commonly the result of parent-to-child transmission. The evolution of sign bilingualism at the individual level is discussed from a developmental linguistics perspective on the basis of a longitudinal investigation of deaf learners' bilingual acquisition of German sign language (DGS) and German. The case studies included in this volume offer unique insights into bilingual deaf learners’ sign language and written language productions, and the sophisticated nature of the bilingual competence they attain. Commonalities and differences between sign bilingual language development in deaf learners and language development in other language acquisition scenarios are identified on the basis of a dynamic model of change in the evolution of (learner) language, with a focus on the role of language contact in the organisation of multilingual knowledge and the scope of inter- and intra-individual variation in learner grammars. In many respects, as becomes apparent throughout the chapters of this work, sign bilingualism represents not only a challenge but also a resource. Given this cross-disciplinary perspective, the insights on bilingualism and deafness in this volume will be of interest to a wide range of researchers and professionals.

For centuries, interest in Shakespeare’s Hamlet has prioritised its brooding, melancholy prince. Yet, over time, the enigmatic Ophelia, his tragic love interest, has risen to prominence in painting, film, television, and beyond, focused especially on her madness and death – conspicuously off-stage in the drama itself. Analysing her rebirth, resurrection, and ghostly afterlives in ‘straight’ adaptations as well as narratives far removed from the Bard’s play, this study offers an innovative cross-media analysis of Ophelia’s evolving representation. Tracing her journey from marginal character to symbol of increasing yet ambivalent transcultural importance, it identifies a series of recurring tropes that re-write her female subjectivity in surprising and fascinating ways. From page to stage, and scene to screen, Ophelia’s voice is by turns amplified, ventriloquised, mediated, and silenced, reshaped by the delicate dialogue between text and image. This book is a captivating exploration of one of Shakespeare’s most evocative figures and her enduring impact on visual storytelling.

By the late 1980s and early 1990s, a great number of TV shows and music acts blossomed in Colombia, all of which resorted to regional identity as the narrative core for a renewed idea of national identity. Among them was “Clasicos de la provincial,” an album by Colombian singer Carlos Vives and his band La Provincia (1993), which marked the beginning of a successful career that has spanned nearly three decades. Vives´s work not only earned much deserved recognition in the musical industry from the beginning, but most importantly, has come to be renowned as a landmark in the cultural history of Colombia. This book is the first in-depth analysis focused on the creation and production process of Vives´s work, its main musical and literary features, and its influence on other musicians and in the construction of a narrative about national identity that is still relevant today. More than fifty interviews with Vives and members of the band, musicians, journalists, radio programmers, musical producers, and other key players of the process, together with an extensive review of hundreds of documents, are the sources for this book, which earned its authors a national award in Colombia (2015).

Black in Print examines the role of narrative, from traditional writing to new media, in conversations about race and belonging in the isthmus. It argues that the production, circulation, and consumption of stories has led to a trans-isthmian imaginary that splits the region along racial and geographic lines into a white-mestizo Pacific coast, an Indigenous core, and a Black Caribbean. Across five chapters, Jennifer Carolina Gómez Menjívar identifies a series of key moments in the history of the development of this imaginary: Independence, Intervention, Cold-War, Post-Revolutionary, and Digital Age. Gómez Menjívar's analysis ranges from literary beacons such as Rubén Darío and Miguel Ángel Asturias to less studied intellectuals such as Wingston González and Carl Rigby. The result is a fresh approach to race, the region, and its literature. Black in Print understands Central American Blackness as a set of shifting coordinates plotted on the axes of language, geography, and time as it moves through print media.