Search

Fully updated and expanded to reflect recent advances, this Fourth Edition of the classic text provides students and professional chemists with an excellent introduction to the principles and general properties of organometallic compounds, as well as including practical information on reaction mechanisms and detailed descriptions of contemporary applications.

The Bourbon monarchs who ascended the Spanish throne in 1700 attempted to reform the colonial system they had inherited, and, in particular, to make administration more efficient and cost-effective. This book analyses one aspect of the Bourbon reforms, which was the efforts to transform frontier missions, to make the missions more cost-effective, and to accelerate the integration of indigenous peoples in northern Mexico to European cultural norms. In some instances, the Crown had funded missions for more than a century, but with minimal results. The book attempts to show how the mission programs changed, and what the consequences – especially demographic – were for the indigenous peoples brought to live on the missions.

The gold standard reference for all those who work with people with mental illness, Kaplan & Sadock's Comprehensive Textbook of Psychiatry, edited by Drs. Robert Boland and Marcia L. Verduin, has consistently kept pace with the rapid growth of research and knowledge in neural science, as well as biological and psychological science. This two-volume eleventh edition offers the expertise of more than 600 renowned contributors who cover the full range of psychiatry and mental health, including neural science, genetics, neuropsychiatry, psychopharmacology, and other key areas.

Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice. - Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century - Includes updates connecting historic research to ongoing advances - Authored by a thought-leader in the field

Rapid Results! shows how to make large-scale changes succeed by using 100-day results-producing projects to develop this vital implementation capability. Written by Robert H. Schaffer, Ronald N. Ashkenas, and their associates--leaders in the field of change management--Rapid Results! describes an approach that has been field-tested by real organizations of every size and description to improve performance and speed the pace of change. Rapid results projects produce results quickly, introduce new work patterns, and enable participants to learn a variety of lessons about managing change. Step by step, the book describes how the use of rapid-cycle, or 100-day, projects will multiply your organization's power to succeed at large-scale change. Schaffer and Ashkenas specifically outline the concept behind 100-day projects and show you how to Set up the architecture to implement rapid results projects Improve operational performance and also attain hard results in the soft areas of management Build rapid results into major organizational change such as reorganization, acquisition integration, and international development Use rapid results to drive leadership development and culture change

Between 1769 and 1834, Franciscan missionaries from the Apostolic College of San Fernando in Mexico City administered missions in what today is California. The Franciscans attempted to convert the indigenous peoples to Catholicism, and reshape their society and culture along with European norms. In 1824, three years after Mexico gained its independence from Spain, Chumash neophytes rebelled following the flogging by a Mexican soldier of a neophyte at Mission Santa Inés. The rebellion quickly spread to two other missions, and lasted a month until soldiers defeated the rebels. This book analyzes the long and short-term causes of the uprising, and the larger historical context. It focuses on the development of Mission La Purísima Concepción where the rebellion lasted the longest. A root cause of the uprising was deteriorating conditions of life on the missions resulting from the outbreak of the independence war in Mexico in 1810.

The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.