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How to use nonlinear dynamic models in policy analysis. Policymakers need quantitative as well as qualitative answers to pressing policy questions. Because of advances in computational methods, quantitative estimates are now derived from coherent nonlinear dynamic macroeconomic models embodying measures of risk and calibrated to capture specific characteristics of real-world situations. This text shows how such models can be made accessible and operational for confronting policy issues. The book starts with a simple setting based on market-clearing price flexibility. It gradually incorporates departures from the simple competitive framework in the form of price and wage stickiness, taxes, rigidities in investment, financial frictions, and habit persistence in consumption. Most chapters end with computational exercises; the Matlab code for the base model can be found in the appendix. As the models evolve, readers are encouraged to modify the codes from the first simple model to more complex extensions. Computational Macroeconomics for the Open Economy can be used by graduate students in economics and finance as well as policy-oriented researchers.

As an active surgeon and former department chairman, Dr. Paul A. Ruggieri has seen the good, the bad, and the ugly of his profession. In Confessions of a Surgeon, he pushes open the doors of the O.R. and reveals the inscrutable place where lives are improved, saved, and sometimes lost. He shares the successes, failures, remarkable advances, and camaraderie that make it exciting. He uncovers the truth about the abusive, exhaustive training and the arduous devotion of his old-school education. He explores the twenty-four-hour challenges that come from patients and their loved ones; the ethics of saving the lives of repugnant criminals; the hot-button issues of healthcare, lawsuits, and reimbursements; and the true cost of running a private practice. And he explains the influence of the "white coat code of silence" and why patients may never know what really transpires during surgery. Ultimately, Dr. Ruggieri lays bare an occupation that to most is as mysterious and unfamiliar as it is misunderstood. His account is passionate, illuminating, and often shocking-an eye-opening, never- before-seen look at real life, and death, in the O.R.

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

The celebrated authors present an in-depth overview of the molecular structures and mechanisms that underlie the utilization of genetic information by complex organisms. They emphasize the experimental aspects of molecular genetics, offering a complete introduction to both principles and methods. "Excellent, suitably detailed and superbly written." Philip Leder, Harvard Medical School

Learn to assess published research in this best-selling introduction to evidence-based healthcare Evidence-based practices have revolutionized medical care. Clinical and scientific papers have something to offer practitioners at every level of the profession, from students to established clinicians in medicine, nursing and allied professions. Novices are often intimidated by the idea of reading and appraising the research literature. How to Read a Paper demystifies this process with a thorough, engaging introduction to how clinical research papers are constructed and how to evaluate them. Now fully updated to incorporate new areas of research, readers of the seventh edition of How to Read a Paper will also find: A careful balance between the principles of evidence-based healthcare and clinical practice New chapters covering consensus methods, mechanistic evidence, big data and artificial intelligence Detailed coverage of subjects like assessing methodological quality, systemic reviews and meta-analyses, qualitative research, and more. How to Read a Paper is ideal for all healthcare students and professionals seeking an accessible introduction to evidence-based healthcare – particularly those sitting undergraduate and postgraduate exams and preparing for interviews.

American economic history describes the transition of a handful of struggling settlements on the Atlantic seaboard into the nation with the most successful economy in the world today. As the economy has developed, so have the methods used by economic historians to analyze the process. Interest in economic history has sharply increased in recent years among the public, policy-makers, and in the academy. The current economic turmoil, calling forth comparisons with the Great Depression of the 1930s, is in part responsible for the surge in interest among the public and in policy circles. It has also stimulated greater scholarly research into past financial crises, the multiplier effects of fiscal and monetary policy, the dynamics of the housing market, and international economic cooperation and conflict. Other pressing policy issues--including the impending retirement of the Baby-Boom generation, the ongoing expansion of the healthcare sector, and the environmental challenges imposed by global climate change--have further increased demand for the long-run perspective given by economic history. Confronting this need, The Oxford Handbook of American Economic History affords access to the latest research on the crucial events, themes, and legacies of America's economic history--from colonial America, to the Civil War,up to present day. More than fifty contributors address topics as wide-ranging as immigration, agriculture, and urbanization. Over its two volumes, this handbook gives readers not only a comprhensive look at where the field of American economic history currently stands but where it is headed in the years to come.

'Learning Disability' uses a life-cycle approach to show how those with learning disabilities can he helped most at different stages in their lives.

This book undertakes the first general assessment of ecological economics from a Marxist point of view, and shows how Marxist political economy can make a substantial contribution to ecological economics. The analysis is developed in terms of four basic issues: (1) nature and economic value; (2) the treatment of nature as capital; (3) the significance of the entropy law for economic systems; (4) the concept of sustainable development. In each case, it is shown that Marxism can help ecological economics fulfill its commitments to multi-disciplinarity, methodological pluralism, and historical openness. In this way, a foundation is constructed for a substantive dialogue between Marxists and ecological economists.

Gastrointestinal (GI) cancers account for nearly 150,000 deaths each year, in the United States alone. Encouragingly, environmental risk factors, premalignant conditions, and high-risk familial kindreds are well described for many GI cancers. In this comprehensive volume on GI Neoplasia, all luminal cancers will be discussed, along with pancreas cancer, gastrointestinal stromal tumors (GISTs), carcinoid tumors, and neuroendocrine tumors. Hepatobiliary cancers are not addressed, as these tumors could form the basis of a separate volume. Articles are organized to address several key topics for each cancer type, such as: public health burden, molecular pathways, risk and protective factors, early detection, clinical evaluation, management, and survivorship.