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This comprehensive textbook offers an in-depth exploration of how thyroid hormones influence brain development and function, particularly on cellular and molecular mechanisms. Readers will find current insights into the complex interplay between the thyroid and neurological systems, making it a valuable resource for researchers, advanced learners and clinicians in the fields of endocrinology, neuroscience, and developmental biology. The book starts with a review of thyroid physiology, setting the stage for subsequent chapters that cover specific topics such as the impact of maternal thyroid hormones on fetal brain development and the effects of iodine deficiency. From here, the book progresses to cover the regulation of brain gene expression, neuronal and glial cell differentiation, and myelination by thyroid hormones, and how thyroid hormones shape the brain. Finally, the book addresses the link between thyroid dysfunction and mood disorders. Key features - A thorough examination of the historical and the latest research findings through 14 chapters - Clear explanations of molecular pathways - Emphasis on both theoretical knowledge and practical applications - Detailed and research-focused content scientific references for further reading.

VII. Freedom of expression.

The popular series Narcos captures only half the truth. This riveting, deeply personal memoir by Pablo Escobar's son reveals the full story.

Root-knot nematodes of the genus Meloidogyne represent one of the most damaging and agricultural important group of plant-parasitic nematodes. These nematodes are obligate sedentary endoparasites infecting most species of higher plants and have a cosmopolitan distribution. Annual worldwide economic losses due to nematode infection of crops have been estimated at several hundred billion US dollars. This book is the first complete illustrated compendium of root-knot nematode species and contains 98 species descriptions with comprehensive diagnoses, information on biology, plant-hosts, pathogenicity, symptoms, distribution and biochemical and molecular diagnostics. It also includes introductions into morphology, biology, biogeography, genomics, phylogeny and host-parasite relationships of root-knot nematodes.

This book is the result of ten years’ of scientific research carried out by the authors on Isla de los Estados. The research includes their doctoral thesis and many published scientific papers related to the island. The book is divided into two principal parts. The first part covers different social and natural aspects of this remote island and includes chapters on the scientific and historical background, physiography with topographical and hydrographical descriptions, climate and oceanographic circulation, vegetation and geology (including stratigraphy, structural geology and geological history). The second part comprises a reconstruction of the paleoenvironmental, paleoclimatic and paleogeographic history of the island from the Last Glacial Maximum to the present, correlating with other paleoecological records from the southern part of Isla Grande de Tierra del Fuego and Patagonia. This second part also includes a geomorphological chapter with a characterization of the principal erosive glacial landforms on Isla de los Estados constructed by means of morphometric analysis, inventories, maps, paleogeographic and glacial models, and a paleoecological chapter evaluating the palaeoenvironment and palaeoclimatic conditions that prevailed during the Late Pleistocene-Holocene times based on pollen and diatom analysis from three 14C-dated peat bogs and lakes. Finally, the book concludes with a review of the island’s archaeology and the relationship between the palaeoenvironmental history and human occupation of this island.

When the Liberal Party reached power in Panama in 1912 it started a period that lasted until 1941. A period in which Panamanians, due to the special circumstances under which the country became independent, the presence of the United States, and of thousands of foreign workers in its territory, began to doubt and asked themselves if they were truly independent. The American presence impacted politics and a sense of inferiority developed because people believed that nothing could be accomplished without the blessings of the United States. In the middle of chaotic political scene and self-doubt, the country retreated to its Hispanic past and began an effort to Hispanize in the face of so much foreign presence and influence, and tried to show the world that Panama was an independent country with history and traditions, and not an appendage of the United States. Belisario Porras, who became president in 1912, emphasized the Hispanic past and built statues to Balboa and Cervantes. Acción Comunal, founded in 1923, promoted nationalism and criticized the corrupt nature of politics. It led a successful campaign against the 1926 Treaty and a coup in 1931. This new generation repudiated the generation that made the 1903 Treaty. “Panama for Panamanians” became one of the catch phrases for the Panamanian youth of the 1920’s and 1930’s, which found in the brothers Harmodio and Arnulfo Arias the leading exponents.

A sweeping history of the Latino experience in the United States- thoroughly revised and updated. The first new edition in ten years of this important study of Latinos in U.S. history, Harvest of Empire spans five centuries-from the first New World colonies to the first decade of the new millennium. Latinos are now the largest minority group in the United States, and their impact on American popular culture-from food to entertainment to literature-is greater than ever. Featuring family portraits of real- life immigrant Latino pioneers, as well as accounts of the events and conditions that compelled them to leave their homelands, Harvest of Empire is required reading for anyone wishing to understand the history and legacy of this increasingly influential group.

An engaging introduction to Latin America with a fresh, thematic approach to key political and social issues. This accessible undergraduate textbook examines the entirety of the region, addressing complex issues in a clear and direct manner. Grounded in cutting-edge research and data, concepts are illustrated through tables, maps, and timelines.

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.