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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

THE INSTANT SUNDAY TIMES BESTSELLER 'A wonderful collection, brilliant and often moving ... Both mind-expanding and cosmic while utterly rooted in our urban reality' NEIL GAIMAN 'One of the great fiction minds of his generation' ROLLING STONE In his first-ever short story collection, which spans forty years of work and features many never-before-published pieces, international bestselling author and legendary creator of From Hell, The League of Extraordinary Gentlemen and other modern classics, Alan Moore, presents nine stories full of wonder and strangeness, each taking us deeper into the fantastical underside of reality. In A Hypothetical Lizard, two concubines in a brothel for fantastical specialists fall in love, with tragic ramifications. In Not Even Legend, a paranormal study group is infiltrated by one of the otherworldly beings they seek to investigate. In Illuminations, a nostalgic older man decides to visit a seaside resort from his youth and finds the past all too close at hand. And in the monumental novella What We Can Know About Thunderman, which charts the surreal and Kafkaesque history of the comics industry over the last seventy-five years through several sometimes-naive and sometimes-maniacal people rising and falling on its career ladders, Moore reveals the dark, beating heart of the superhero business. From ghosts and otherworldly creatures to theoretical Boltzmann brains fashioning the universe at the big bang, Illuminations is exactly that - a series of bright, startling tales from a contemporary legend that reveal the full power of imagination and magic. 'One of the most significant fiction writers in English ... Moore's influence can be felt everywhere -- in our literature, on our screens, in our politics' GUARDIAN Illuminations became a Sunday Times Top 5 Bestseller on 15th October 2022

NATIONAL BESTSELLER NEW YORK TIMES BOOK REVIEW EDITORS' CHOICE From New York Times bestselling author Alan Moore—one of the most influential writers in the history of comics—"a wonderful collection, brilliant and often moving" (Neil Gaiman) which takes us to the fantastical underside of reality.

Blindfold Games was the first volume of Alan Ross's autobiography. He was a most attractive man. William Boyd has eloquently described his appeal, 'There was a sophisticated raffishness and glamour about him . . . nothing seedy or earnest. He owned racehorses. He loved women and travel. . . He was a poet and a brilliant writer on cricket.' He was also one of the great literary editors, running the London Magazine in its heyday. This volume begins in Bengal, where he was born, and ends in Germany in 1946 when the author was twenty-four. It takes in his childhood in India, his schooldays in England, his time at Oxford, and, most hauntingly, his experiences on the Arctic convoys during the Second World War. He survived: very many of his friends were killed. To give it a less humdrum description one can turn to the author's own words. 'War, India, cricket: these were my first subjects as a writer and they remain the preoccupations of this book. In due course, the playing of games was replaced by writing about them, and it was to the belief that the best characteristics of each derive from the same source that I nailed my colours. The searching for 'suitable similes' . . . whether for Hammond's off-drive, Stanley Matthews' mesmeric dribbling, or a racehorse's action, was as good a way as I could imagine of relating techniques to aesthetics. . . Perhaps, as much as anything, writing this book has been an attempt to reconcile differing definitions of style and to trace the manner in which a single-minded devotion to sport developed into a passion for poetry.' 'An exceptional autobiography, beautifully written' John Carey 'A beautifully composed book' Raleigh Trevelyan 'A Delightful account of the first part of his life, which, I shall lay odds, is likely to become a classic' Allan Massie, Listener 'A brilliant performance' Anthony Curtis

'One of the great fiction minds of his generation' ROLLING STONE In his first-ever short story collection, which spans forty years of work and features many never-before-published pieces, international bestselling author and legendary creator of From Hell, The League of Extraordinary Gentlemen and other modern classics, Alan Moore, presents nine stories full of wonder and strangeness, each taking us deeper into the fantastical underside of reality. In A Hypothetical Lizard, two concubines in a brothel for fantastical specialists fall in love, with tragic ramifications. In Not Even Legend, a paranormal study group is infiltrated by one of the otherworldly beings they seek to investigate. In Illuminations, a nostalgic older man decides to visit a seaside resort from his youth and finds the past all too close at hand. And in the monumental novella What We Can Know About Thunderman, which charts the surreal and Kafkaesque history of the comics industry over the last seventy-five years through several sometimes-naive and sometimes-maniacal people rising and falling on its career ladders, Moore reveals the dark, beating heart of the superhero business. From ghosts and otherworldly creatures to theoretical Boltzmann brains fashioning the universe at the big bang, Illuminations is exactly that - a series of bright, startling tales from a contemporary legend that reveal the full power of imagination and magic. 'One of the most significant fiction writers in English ... Moore's influence can be felt everywhere-in our literature, on our screens, in our politics' GUARDIAN Illuminations became a Sunday Times Top 5 Bestseller on 15th October 2022

Alan Lomax (1915-2002) began working for the Archive of American Folk Song at the Library of Congress in 1936, first as a special and temporary assistant, then as the permanent Assistant in Charge, starting in June 1937, until he left in late 1942. He recorded such important musicians as Woody Guthrie, Muddy Waters, Aunt Molly Jackson, and Jelly Roll Morton. A reading and examination of his letters from 1935 to 1945 reveal someone who led an extremely complex, fascinating, and creative life, mostly as a public employee. While Lomax is noted for his field recordings, these collected letters, many signed "Alan Lomax, Assistant in Charge," are a trove of information until now available only at the Library of Congress. They make it clear that Lomax was very interested in the commercial hillbilly, race, and even popular recordings of the 1920s and after. These letters serve as a way of understanding Lomax's public and private life during some of his most productive and significant years. Lomax was one of the most stimulating and influential cultural workers of the twentieth century. Here he speaks for himself through his voluminous correspondence.

Following the treaty of Utrecht, Portugal, successful diplomatically where she had failed militarily, embarked on a lengthy period of balancing the interests of Britain, France and Spain against her own political and economic needs. This study, drawing extensively on state papers and other collections, follows the course of Anglo-Portuguese relations through the years of John V, the age of Pombal and the 1762 war with Spain, to the years of the French revolution and the flight of the court to Brazil under the threat of Napoleon's army.