TEXT BOOK OF MEDICINAL CHEMISTRY-I

The Text Book of Medicinal Chemistry-I offers an in-depth exploration of medicinal chemistry, aligning with the core curriculum for pharmacy and medicinal chemistry students. The book begins by detailing the history and evolution of medicinal chemistry, providing a foundation for understanding how drug properties influence biological action. Readers gain insights into key physicochemical concepts such as ionization, solubility, hydrogen bonding, and bioisosterism, essential for drug design. Following this introduction, the book covers drug metabolism processes, focusing on Phase I and Phase II reactions and factors influencing metabolic rates, including stereochemistry. The autonomic nervous system is extensively covered, with sections on adrenergic and cholinergic neurotransmitters, discussing their biosynthesis, metabolism, and receptor types. Each chapter delves into various drug classes such as sympathomimetic and parasympathomimetic agents, providing the mechanism of action, therapeutic uses, and Structure-Activity Relationship (SAR) insights. Key classes of drugs, including adrenergic antagonists, cholinergic blockers, sedatives, hypnotics, antipsychotics, anticonvulsants, general anesthetics, and analgesics, are systematically analyzed. Emphasis is placed on the synthesis and SAR of specific drugs marked with asterisks, aiding students in understanding the chemical intricacies and development of active compounds. Additional sections provide comprehensive coverage of sedatives, anticonvulsants, and anesthetics, offering readers an analytical view of their therapeutic action and SAR. Designed for in-depth study, this book is a critical resource for students aiming to grasp medicinal chemistry concepts, from foundational knowledge to advanced applications in drug synthesis and analysis.