Genetics of Disease

This book is based on previous findings of various association studies conducted in different population of the world. Human genetic studies and association of genetic polymorphisms with disease has been assisted in finding of causes of disease and development of molecular medicine. After discovery of genetic material scientists are continuously working to understand the genes involved to various biochemical and metabolic pathways. Genetics has now opened the door of new era to understand the possible role of genes in many disorders including diabetes, hypertension, thyroidism, cancer and many other autoimmune diseases. The disorders in metabolism could be due to lack of normal expression of gene and their functional proteins. This abnormality could be arising in the gene due to the presence of specific polymorphic allele of particular gene and due to this polymorphism.

Many genetic studies already did in past clearly indicate the role of genetic base and mutations (SNPs and VNTR) could be responsible to increase the susceptibility of many disease. Genetic association study as well as proteomic studies has introduced a new dimension to understand the possible role of genetic polymorphisms in metabolic and life threatening disorders. The disorders in metabolism could be due to lack of normal expression of gene and their functional proteins. This abnormality could arise in the genes due to the presence of specific polymorphic allele of particular gene. Many genetic studies already conducted which clearly indicate the role of genetic factors in the susceptibility of disease causation. We hope that this book will be helpful to readers to understand the importance of genetic base in disease susceptibility.

Dr. Arvind Kumar Tripathi