Toxicity Report on Toxicity Studies of Wy-14,643 (CAS NO. 50892-23-4) Administered in Feed to Male Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters

Wyeth-14,643 is a chemical that was developed by the pharmaceutical industry to lower serum cholesterol. It is not used in clinical applications. This study examined the effects of Wyeth-14,643 on rats, mice, & hamsters because it was known that this chemical promotes the production of peroxisomes, organelles that contain a variety of enzymes involved in metabolism of lipids & cholesterols. Results show that exposure to Wyeth-14,6453 caused changes in the livers of male rats, mice, & hamsters, including increased liver weights, increases in cytoplasmic alteration of the liver, & some liver foci. Wyeth-14,643 also had effects on the testes of exposed male rodents, decreasing the spermatid counts & the weights of the cauda epididymis. Illus.