It is equally significant, writes Anderson, that Joseph's mother suffered bouts of depression. For instance, "for months" she "did not feel as though life was worth seeking" after two sisters died of tuberculosis and later when she buried two sons, Ephraim and Alvin. A typhoid epidemic nearly claimed her daughter Sophronia, and the same affliction left Joseph with a crippled leg, after which he was sent to live on the coast with an uncle. Such factors and others produced emotional wounds that emerged later in the prophet's life and writings, in particular, according to Anderson, in the Book of Mormon.