What will later become the legendary St. James-Goldstein duo at Yale begins on the day World War II breaks out in Europe. Harold St. James and Izzy Goldstein meet on the train to New Haven, Connecticut, and both learn that they will be working together in two different departments in the same building at Yale.
Their oddball friendship becomes fodder for snide comments and campus newspaper articles. But it's a strong friendship that carries them through an initial anti-Semitism, Harold's marriage and his wife's premature death, the House Un-American Activities Committee, the Vietnam War, and the Black Panthers.