Annual Review of Pharmacology and Toxicology

Papers detail research and findings surrounding advances in the field. Topics include regulation and role in drug metabolism of cytochrome P- 450 3A4, molecular and pharmacologic regulation of the pineal gland, regulation of gene expression by reactive oxygen, cytotoxicity of short-chain alcohols, glial cells in neurotoxicity development, and regulation and inhibition of phospholipase A2. Other subjects include inhibition of nitric oxide synthase as a potential therapeutic target, genetic regulation of glutamate receptor ion channels, and teratology of retinoids. Annotation copyrighted by Book News, Inc., Portland, OR