An analysis of key missiological concepts, such as mission histories, ethno-theologies, worldview, culture, ethnic cohesion, and contextualization is appropriated to illuminate the theological voices and evangelical practices of a specific people, or ethnicity, shaped by a journey of spiritual faith. While the numerical significance of self-identified African-American Presbyterians may appear small, their synergistic encounter of human identity and religious faith, historical experience in the church, and the impact of their evangelical presence provide an excellent case study for discerning the twenty-first-century challenges of evangelism. This thorough study of history, theology, organizational structures, methods, and techniques will serve as a valuable tool in evaluating the impact of the faith journey of African-American Presbyterians and its challenges for today and the future.