Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Benzene (CAS NO. 71-43-1) in Genetically Modified Haplo-insufficient P16Ink4a/p19Arf Mice (Gavage Study)

Benzene is used primarily as a solvent in the chemical & pharmaceutical industries, as a starting material & intermediate in the synthesis of numerous chemicals, & in gasoline. The major U.S. source of benzene is petroleum. Benzene has been previously evaluated in 2-year carcinogenicity studies. In this study, the carcinogenic effects of benzene were studied in the haplo-insufficient p16Ink4a/p19Arf mouse model as part of an ongoing effort to seek improved model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic information relative to understanding an agent¿s mode of action. Illustrations.