The updated edition of this popular textbook offers an overview of the major components of the field, including signal processing in bio-systems, biomechanics, and biomaterials. Introducing capstone design and entrepreneurship, the second edition examines basic engineering, anatomy, and physiology concepts to facilitate an in-depth and up-to-date understanding of flow, transport, and mechanics in biological systems and the human body. The book begins by addressing the principles of conservation of mass and development of mathematical models of physiological processes with detailed examples appropriate for an engineering student at the sophomore or first semester junior level.