This book shares the lessons learned by a large community of educational researchers and science teachers as they designed, developed, and investigated a new technology-enhanced learning environment known as WISE: The Web-Based Inquiry Science Environment. WISE offers a collection of free, customizable curriculum projects on topics central to the science standards as well as guidance for teachers on how these Internet-based projects can be used to improve learning and instruction in their science classrooms (grades 6–12). Hundreds of teachers and over 100,000 students have learned from WISE projects taught in English, Norwegian, Dutch, German, Hebrew, Chinese, and Korean. Highlights of WISE include: